Protein Alignment CG16789 and CDC48

DIOPT Version :10

• Sequence 1: NP_649910.3
• Gene: CG16789 / 41154
• FlyBaseID: FBgn0037712
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_010157.1
• Gene: CDC48 / 851431
• SGDID: S000002284
• Length: 835
• Species: Saccharomyces cerevisiae
• Alignment Length: 781
• Identity: 152/781 - (19%)
• Similarity: 259/781 - (33%)
• Gaps: 244/781 - (31%)

  Fly    89 LVRKLLDACLGRVVELKHDLVNIDLMEFSYNDEVVERLRLTPMETEL------------------ 135
            |.||..|..|     |..|.:|.|....:.|...:::|.|...:|.|
Yeast    27 LRRKKKDNML-----LVDDAINDDNSVIAINSNTMDKLELFRGDTVLVKGKKRKDTVLIVLIDDE 86

  Fly   136 ---------RIPRYFLRERQQELEFRKKTMH-----EILTKLGWLEEHELEETVTTE-------- 178
                     |:.|..||.|..:|    .|:|     :..|::..|...:..|.:|..
Yeast    87 LEDGACRINRVVRNNLRIRLGDL----VTIHPCPDIKYATRISVLPIADTIEGITGNLFDVFLKP 147

  Fly   179 --IEAIRMLQM--HERARQGRLRAHF------------MKEIRILKEKGKSEERTEKERSDSGLL 227
              :||.|.::.  |...|.|..:..|            :.:..|:..:|:...| |.|.::...:
Yeast   148 YFVEAYRPVRKGDHFVVRGGMRQVEFKVVDVEPEEYAVVAQDTIIHWEGEPINR-EDEENNMNEV 211

  Fly   228 AAMKIQKMWRGHTARRITRRRKMEEMIL--------IGMLPP-------PP---------AVVKE 268
            ....|     |...:::.:.|:|.|:.|        ||:.||       ||         ||..|
Yeast   212 GYDDI-----GGCRKQMAQIREMVELPLRHPQLFKAIGIKPPRGVLMYGPPGTGKTLMARAVANE 271

  Fly   269 RA---------EKLEKLQHNEKRYQAQAFYGKEFEERQNAL--KEEI------RAKHGASMKEDI 316
            ..         |.:.|:....:....:||  :|.|:...|:  .:||      |.|....::..:
Yeast   272 TGAFFFLINGPEVMSKMAGESESNLRKAF--EEAEKNAPAIIFIDEIDSIAPKRDKTNGEVERRV 334

  Fly   317 ADEIRAWVKDCYDKTGKLPDFPSEDQGGS----LHIFSRPGTESEHSRSSARSSKESRKTKDKSK 377
            ..::.. :.|.......:....:.::..|    |..|.|...|.:.....|....|..:...|:.
Yeast   335 VSQLLT-LMDGMKARSNVVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEVLRIHTKNM 398

  Fly   378 SPARSGDLNVNENQDEEVSFQPAPSVC----LPDIRAEIDLFNDTWRDKDETGVLSQAAYEDMIY 438
            ..|...||.....:..........|:|    :..||.::||.     |.||
Yeast   399 KLADDVDLEALAAETHGYVGADIASLCSEAAMQQIREKMDLI-----DLDE-------------- 444

  Fly   439 SDKYQEVELEFRRAVDDVMRQEIELLQTAVGKKVKKSSKKTRRSGKKSKKKKEKDLTP-DRTTES 502
                .|::.|    |.|.:...::..:.|:|   ..:....|.:..:|......|:.. |...|.
Yeast   445 ----DEIDAE----VLDSLGVTMDNFRFALG---NSNPSALRETVVESVNVTWDDVGGLDEIKEE 498

  Fly   503 LYEELVTNGIIRKYPELRLKQFLGDKALTARIGTNPSPGDIRQILTEYCILPLGSDAIHNCTPLI 567
            |.|.:       :||.|...|:       .:.|.:||.|
Yeast   499 LKETV-------EYPVLHPDQY-------TKFGLSPSKG-------------------------- 523

  Fly   568 RSILLAGPKGSGKKALLHAICTEVGAVLFDLTPANIVGKYPGKSGLIMLIHLVLKVSRLLQPAVI 632
              :|..||.|:||..|..|:.|||.|....:....::..:.|:|.  ..|..:...:|...|.|:
Yeast   524 --VLFYGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGESE--SNIRDIFDKARAAAPTVV 584

  Fly   633 F--------------MGDA----ERPFMKKIPKTDRTDPKRLKKDLPKLIKNIAPEDRVVFIGTS 679
            |              :|||    :|...:.:.:.|..:.|:                .|..||.:
Yeast   585 FLDELDSIAKARGGSLGDAGGASDRVVNQLLTEMDGMNAKK----------------NVFVIGAT 633

  Fly   680 NLPWEADQKLLQ-SVYNRFIYIPRPDYGAM-----SHAWKTLLHDYSGGISNLDTSAMAKISDGY 738
            |.|.:.|..:|: ...::.||:|.||..|.     :...||.|.      ..|:.:|:||.:.|:
Yeast   634 NRPDQIDPAILRPGRLDQLIYVPLPDENARLSILNAQLRKTPLE------PGLELTAIAKATQGF 692

  Fly   739 T 739
            :
Yeast   693 S 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16789	NP_649910.3	DUF5401	<131..>307	CDD:375164	51/272 (19%)
		SpoVK	443..773	CDD:440232	67/322 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	542..700	CDD:476819	33/176 (19%)
CDC48	NP_010157.1	CDC48	48..785	CDD:273521	143/755 (19%)