Protein Alignment CG16789 and DRC11

DIOPT Version :10

• Sequence 1: NP_649910.3
• Gene: CG16789 / 41154
• FlyBaseID: FBgn0037712
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_001257514.1
• Gene: DRC11 / 79781
• HGNCID: 26195
• Length: 830
• Species: Homo sapiens
• Alignment Length: 835
• Identity: 309/835 - (37%)
• Similarity: 511/835 - (61%)
• Gaps: 76/835 - (9%)

  Fly     6 FNDIWHQSQH------ECELLSTIDYERQHQDVETTVATMNAAVGSVAADADAKALLQSSLYEFY 64
            :|.:|||:|.      :.|....|:.:|....:..|:||                        ||
Human    13 YNKMWHQTQEALGALLDKEPQKMIEPQRNQVFIFQTLAT------------------------FY 53

  Fly    65 LRYICLSNRLEDVYDNMIQPQKRQLVRKLLDACLGRVVELKHDLVNIDLMEFSYNDEVVERLRLT 129
            ::|:.:...||:|||..:.||||.|:||:||..:||::|||:::|.::|.||.|.|::::.|:|.
Human    54 VKYVQIFRNLENVYDQFVHPQKRILIRKVLDGVMGRILELKNEMVELELTEFHYFDDILQDLKLA 118

  Fly   130 PMETELRIPRYFLRERQQELEFRKKTMHEILTKLGWLEEHELEETVTT--EIEAIRMLQMHERAR 192
            |.:.::.||:|||:|:.:.::.|:|.:.:||...| ::..:::..|.:  ..||::::|:.||||
Human   119 PQQLDIPIPKYFLKEKLEVIKGREKILAQILADSG-IDTSDMKYPVKSIPFDEAVKLIQIAERAR 182

  Fly   193 QGRLRAHFMKEIRILKEKGKSEERTEKERSDSGLLAAMKIQKMWRGHTARRITRRRKMEEMILIG 257
            ||||||.|||:|.:.:.:.|..:...|:.:|: ..||::|||:||....|:.|.:.:.||||.:|
Human   183 QGRLRALFMKQIYLQEYRAKQSKMLGKKVTDT-WAAALRIQKVWRRFHQRKETEKLREEEMIFLG 246

  Fly   258 MLPPP------PAVVKERAEKLEKLQHNEKRYQAQAFYGKEFEERQNALKEEIRAKHGASMKEDI 316
            |.|||      ..|:  :|||:::|     |.:.|..:.:::.|....:|.:::...|..:||::
Human   247 MNPPPLFNEVSATVI--QAEKVDRL-----RNEVQIKHEEDYREALVTIKNDLKLIEGVDIKENL 304

  Fly   317 ADEIRAWVKDCYDKTGKLPDFPSEDQGGSLHIFSRPGTE---SEHSRSSARSSKESRKTKDKSKS 378
            .|:||.|..:|.:.||..||:|..::|||..|||....:   .:...:.....|..:|.|.|.|.
Human   305 QDQIRHWFIECRNLTGTFPDYPDVEEGGSAIIFSDKTIQQVIEDIIANQEEEEKNKKKKKKKEKQ 369

  Fly   379 PARS-----GDLNVNENQDEEVSFQPAPSVCLPDIRAEIDLFNDTWRDKDETGVLSQAAYEDMIY 438
            |.::     |....|:.:||:  ::.:||:.||.::...:.:.:.|..|||:...||....::|.
Human   370 PKKAKKQKKGTKEKNKEEDEK--WKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYDPELIK 432

  Fly   439 SDKYQEVELEFRRAVDDVMRQEIELLQTAVGKK----VKKSSKKTRRSGKKSKK-----KKEKDL 494
            .:|.:|::.|.|..||::||||::.|:.||.::    ||...||.::.|||.||     ||:|||
Human   433 EEKRKELQSEIRIQVDELMRQELKNLKLAVDRERERPVKAGKKKDKKKGKKGKKKEKKAKKDKDL 497

  Fly   495 TPDRTTESLYEELVTNGIIRKYPELRLKQFLGDKALTA----RIGTNPSPG--DIRQILTEYCIL 553
            |.|||.||||:|||..|::.:..::.|..::|:.:...    ::...|.|.  |:||::|.|.|.
Human   498 TADRTIESLYKELVEEGLLIQALKVNLSDYIGEYSYLGTTLRQVSIEPMPSLLDVRQLITLYGIW 562

  Fly   554 PLGSDAIHNCTPLIRSILLAGPKGSGKKALLHAICTEVGAVLFDLTPANIVGKYPGKSGLIMLIH 618
            ||||.|:|...||::|:|||||.|.|||.|:||||||.||.||:|:.:||.||||||:||.|::|
Human   563 PLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLH 627

  Fly   619 LVLKVSRLLQPAVIFMGDAERPFMKKIPKTDR-TDPKRLKKDLPKLIKNIAPEDRVVFIGTSNLP 682
            .|.||:|.|||:|:::.|.|:.|.||:|..:: .:||||||.||:::|.:.|:||::.:||:..|
Human   628 AVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTRRP 692

  Fly   683 WEADQKLLQSVYNRFIYIPRPDYGAMSHAWKTLLHDYSGGI--SNLDTSAMAKISDGYTIGSIDA 745
            ::|:.:....||.:.|.:|||||.:....||.:: :.:||:  |.|:.|.:||::||:|.|.|..
Human   693 FDAELQSFCKVYQKIILVPRPDYASRYVLWKQII-ERNGGVLTSALNVSCLAKVTDGFTQGHIVE 756

  Fly   746 CLKEVMTCKRKLQLRTQPLTNAELINVLCSRDPVYREEEEAFESWWSKTPLGRRR 800
            .:|.|:|.:|..:...:|||..|.|..:.|.:|||:||||:|::|::|||||::|
Human   757 VVKGVLTDQRIRRQIHKPLTAVEFITAITSMNPVYKEEEESFKNWYAKTPLGKKR 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16789	NP_649910.3	DUF5401	<131..>307	CDD:375164	59/183 (32%)
		SpoVK	443..773	CDD:440232	151/347 (44%)
		P-loop containing Nucleoside Triphosphate Hydrolases	542..700	CDD:476819	81/158 (51%)
DRC11	NP_001257514.1	RecA-like_IQCA1	551..710	CDD:410914	81/158 (51%)