Protein Alignment CG16789 and Nvl

DIOPT Version :10

• Sequence 1: NP_649910.3
• Gene: CG16789 / 41154
• FlyBaseID: FBgn0037712
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_080447.1
• Gene: Nvl / 67459
• MGIID: 1914709
• Length: 855
• Species: Mus musculus
• Alignment Length: 645
• Identity: 131/645 - (20%)
• Similarity: 220/645 - (34%)
• Gaps: 179/645 - (27%)

  Fly   223 DSGLLAAMKIQKMWRGHTARRITRRRKMEEMILIGMLPPPPAVVKERAEKLEKLQHNEKRYQAQA 287
            |:|:||: .:|:::.....||                                 :.|..|.|.:.
Mouse    31 DTGILAS-DLQRLYSVDYGRR---------------------------------KRNAFRIQVEK 61

  Fly   288 FYGKEFEERQNALKEEIRAKHGAS-MKEDIADEIRAWVKDCYDKTGKLPDFPSEDQGGS-----L 346
            .:.....|::....:|:...|.|. .::|..||   :.:...|....:.|:|.......     |
Mouse    62 VFSIISSEKELKNLKELEDGHLAKRARQDEEDE---YTESYSDDDSNMEDYPDPQSANPMNSSLL 123

  Fly   347 HIFSRPGTES-----EHSRSSARSSKESRKTKDKS---KSPARSGD----LNVNENQDEEVSFQP 399
            .::.|..:||     :..:..|.:|.....:|..|   |:|||..:    ::......:|
Mouse   124 SLYRRGNSESVSTTPKWGQREATTSTPLLTSKTGSVPLKTPARESEGGWFIDKTPGGKKE----- 183

  Fly   400 APSVCLPDIRAEIDLFNDTWRDKDETGVLSQAAYEDMIYSDKYQEVELEFRRAVDDVMRQEIELL 464
                .||     :||.:|....|.:...:.......::.|||
Mouse   184 ----SLP-----LDLSDDQSNSKKQDSEIQILKDSSLLESDK----------------------- 216

  Fly   465 QTAVGKKVKKSSKKTRRSGKKSKKKKEKDLTPDRTTESLYEELVTNGIIRKYPELRLKQFLGDKA 529
                       .:|.|..||.:|:|.|.....|...|:|         ::|..:.|..:......
Mouse   217 -----------KRKGRAKGKGNKRKTENLQEVDGEIEAL---------LQKKAKARSTELQISNV 261

  Fly   530 LTARIGTNPSPGDIRQILTEYCILPLGSDAIHNCTPLI---------RSILLAGPKGSGKKALLH 585
            ....:|.|.:      .|.|.|.:     .||...|.:         |.:||.||.|.||..|.|
Mouse   262 KFEDVGGNDA------TLKEVCKM-----LIHMRHPEVYQHLGVVPPRGVLLHGPPGCGKTLLAH 315

  Fly   586 AICTEVGAVLFDLTPANIVGKYPGKSGLIMLIHLVLKVSRLLQPAVIFMGDAERPFMKKIPKTDR 650
            ||..|:...:..:....||....|:|        ..|:..|...||     :..|.:..|.:.|.
Mouse   316 AIAGELDLPILKVAAPEIVSGVSGES--------EQKLRELFDQAV-----SNAPCIVFIDEIDA 367

  Fly   651 TDPKR--LKKDLPKLI-----------KNIAPEDRVVFIGTSNLPWEADQKLLQS-VYNRFIYIP 701
            ..|||  ..||:.:.|           .|:|...||:.||.:|.|...|..|.:: .::|.:.:.
Mouse   368 ITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREVCLG 432

  Fly   702 RPDYGAMSHAWKTLLHDYSGGISNLDTSAMAKISDGYTIGSIDACLKEVMTC-------KRKLQL 759
            .||..|.....:||....... ...:...:|.::.|:....:.|..:|...|       |::.|.
Mouse   433 IPDEAARERILQTLCRKLRLP-ETFNFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKQQAQQ 496

  Fly   760 RTQPLTNAELINVLCSRDPVYREEEEAFESWWSKTPLGRRRQRFLEL--EEERLLEEQAQ 817
            :.:|    |:..:....|    :||.......|:|.  ...||.|.|  :::.|.|||.|
Mouse   497 KKKP----EIEGLPSEGD----QEERLGAEPTSETQ--DELQRLLGLLRDQDPLSEEQMQ 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16789	NP_649910.3	DUF5401	<131..>307	CDD:375164	12/83 (14%)
		SpoVK	443..773	CDD:440232	75/359 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	542..700	CDD:476819	47/180 (26%)
Nvl	NP_080447.1	Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381	1..219		42/272 (15%)
		Nucleolin_bd	2..72	CDD:465247	11/74 (15%)
		Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449	49..52		2/35 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..234		36/201 (18%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	85..88		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	217..231		5/13 (38%)
		CDC48	<242..855	CDD:273521	81/349 (23%)
		Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381	266..473		56/231 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..523		6/34 (18%)