Protein Alignment Vps45 and VPS45

DIOPT Version :10

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_011420.3
• Gene: VPS45 / 852785
• SGDID: S000003063
• Length: 577
• Species: Saccharomyces cerevisiae
• Alignment Length: 591
• Identity: 203/591 - (34%)
• Similarity: 335/591 - (56%)
• Gaps: 53/591 - (8%)

  Fly     1 MNLISGIKLYIEKMCSESG----------PGMKIILLDKETTSIISMAFSQSDMLQREVYLFERL 55
            |||......||.|:.:...          ..:|::||||.||..||:..:||::|:.|:||.||:
Yeast     1 MNLFDVADFYINKIVTSQSKLSVANVNEHQRIKVLLLDKNTTPTISLCATQSELLKHEIYLVERI 65

  Fly    56 DSGRSNERLKYLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESV 120
            :: ...|..::|:|:|:::||::.:|.|..|||||:|..|.|:||||:.::.::.|||.|:.|:|
Yeast    66 EN-EQREVSRHLRCLVYVKPTEETLQHLLRELRNPRYGEYQIFFSNIVSKSQLERLAESDDLEAV 129

  Fly   121 REVKELYADYLCVNPNLFSLGIP--NCMAN-LNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGS 182
            .:|:|::.|:..:|.:|||..:.  ..::| |.|....|.:....:.:||||||:.|.|||...|
Yeast   130 TKVEEIFQDFFILNQDLFSFDLQPREFLSNKLVWSEGGLTKCTNSLVSVLLSLKIKPDIRYEGAS 194

  Fly   183 QAAQLLAKLIYEQITK-ESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHI 246
            :..:.|||.:..:|.| |.:.||| ..||  :.|:||:|||..||:||||..||||:|::|.:.|
Yeast   195 KICERLAKEVSYEIGKNERTFFDF-PVMD--STPVLLILDRNTDPITPLLQPWTYQSMINEYIGI 256

  Fly   247 KNNRLDLSNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRKANDHKKVESI 311
            |.|.:|||..|.:.||.:::.||..||.|:.:.||.|:||:|..:||.:..::.|...:.::.||
Yeast   257 KRNIVDLSKVPRIDKDLEKVTLSSKQDAFFRDTMYLNFGELGDKVKQYVTTYKDKTQTNSQINSI 321

  Fly   312 ADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKL 376
            .|:|||||.||:|:|:||.|.||:.::|||......:|::|:||:||.::....:......:.||
Yeast   322 EDIKNFIEKYPEFRKLSGNVAKHMAIVGELDRQLKIKNIWEISEIEQNLSAHDANEEDFSDLIKL 386

  Fly   377 IADERVSIDDALKLVALYALRYERHANCDTSG-----LLQIIKTRGGRAAIVPSLI----EYAGT 432
            :.:|.|.....|||..:|:|      |..||.     |::|:..:     :.|..:    ::...
Yeast   387 LQNEAVDKYYKLKLACIYSL------NNQTSSDKIRQLVEILSQQ-----LPPEDVNFFHKFKSL 440

  Fly   433 HVRQGDLFNMVRITDAV--KLTRNLIKGLKG----VENVFTQHTPLLKETLEDVFKGRELDPLFP 491
            ..||..:.......|.:  :|.|.....:..    .|||:.||.|.:...|.|:.|.......|.
Yeast   441 FSRQDKMTQSNHDKDDILTELARRFNSRMNSKSNTAENVYMQHIPEISSLLTDLSKNALFRDRFK 505

  Fly   492 AINSE---LVPFRRP---PQEVVVFIIGGATYEEALAVHQLN---NAGYKVILGGTTIHNSQSFI 547
            .|:::   ::..::.   ||:|::|:|||.|||||..||..|   |...:|:||||:|.:::.::
Yeast   506 EIDTQGHRVIGNQQSKDIPQDVILFVIGGVTYEEARLVHDFNGTMNNRMRVVLGGTSILSTKEYM 570

  Fly   548 QEVVAA 553
            ..:.:|
Yeast   571 DSIRSA 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..549	CDD:460020	196/553 (35%)
VPS45	NP_011420.3	SEC1	3..577	CDD:227487	201/589 (34%)