DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps45 and SLY1

DIOPT Version :9

Sequence 1:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_010475.1	Gene:	SLY1 / 851770	SGDID:	S000002597	Length:	666	Species:	Saccharomyces cerevisiae

Alignment Length:	628	Identity:	141/628 - (22%)
Similarity:	261/628 - (41%)	Gaps:	128/628 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIVFIRPTKQNIQLLANEL 87
            |:::||.::|:.||.....:|:|:..:.:...:...||  .|..:..|.|:.|||:||.::.|:|
Yeast    54 KVLILDIKSTATISSVLRVNDLLKAGITVHSLIKQDRS--PLPDVPAIYFVSPTKENIDIIVNDL 116

  Fly    88 RNPKYSAYYIYFSNIIPRTDIKYLAE----CDESESVREVKELYADYLCVNPNLFSLGIPNCMAN 148
            ::.|||.:||.|::.:||..::.||:    ..:|:.:::|.:.|.|::...|.||||.|.|....
Yeast   117 KSDKYSEFYINFTSSLPRNLLEDLAQQVSITGKSDKIKQVYDQYLDFIVTEPELFSLEISNAYLT 181

  Fly   149 LNWLPDALNRSMQGITA--------VLLSLKLNPVIRYRAGSQAAQLLAKLIYEQI------TKE 199
            || .|......:.|:.|        .:|::...|:||...|. .|:::|:.:..::      |..
Yeast   182 LN-DPKTTEEEITGLCANIADGLFNTVLTINSIPIIRAAKGG-PAEIIAEKLGTKLRDFVINTNS 244

  Fly   200 SSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVPKDFK 264
            ||....:.| |.....:|::|||..|..:...|.|.||.||.::..:..|.:      .:|.:.|
Yeast   245 SSTSTLQGN-DSLERGVLIILDRNIDFASMFSHSWIYQCMVFDIFKLSRNTV------TIPLESK 302

  Fly   265 ELVLSG-----------------DQDDFYGNNMYANYGEIGSTIKQLMEEFQRKANDHKK---VE 309
            |   :|                 ..|.|:..|.:..:.|....::..:..::.:|.:..:   |.
Yeast   303 E---NGTDNTTAKPLATKKYDIEPNDFFWMENSHLPFPEAAENVEAALNTYKEEAAEITRKTGVT 364

  Fly   310 SIADM-----------KNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACK 363
            :|:|:           :..::..|:......|:..|:.:...|.:....::|....|:||:....
Yeast   365 NISDLDPNSNNDTVQIQEVVKKLPELTAKKNTIDTHMNIFAALLSQLESKSLDTFFEVEQDPGST 429

  Fly   364 AEHSAQLQRIKKLIADERV-SIDDALK-LVALYAL--------------RYERHANCDTSGLLQI 412
            ...|    |...::.|.:. :::|.|: .:.||..              .|.:..:.|.:.|..:
Yeast   430 KTRS----RFLDILKDGKTNNLEDKLRSFIVLYLTSTTGLPKDFVQNVENYFKENDYDINALKYV 490

  Fly   413 IKTR-----------------GGRAAIVPSLIEYAGTH-VRQGDLFNMVRITDAVKLTRNLIKGL 459
            .|.|                 |..:|..||.:..:|.: :.:|.|...|         .:||.|:
Yeast   491 YKLREFMQLSNMSLQNKSLEDGSDSAFKPSNLTLSGIYGLTEGKLQGGV---------GSLISGI 546

  Fly   460 K---------GVENVFTQ-HTPL--LKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFII 512
            |         .:.||... ..||  .::.||.......:||.....:....|.|:...:.:||::
Yeast   547 KKLLPEKKTIPITNVVDAIMDPLNSSQKNLETTDSYLYIDPKITRGSHTRKPKRQSYNKSLVFVV 611

  Fly   513 GGATYEE-----ALAVHQLNNAGYKVILGGTTIHNSQSFIQEV 550
            ||..|.|     ..|..||:|. .||:.|.|.|.....|:.|:
Yeast   612 GGGNYLEYQNLQEWAHSQLHNP-KKVMYGSTAITTPAEFLNEI 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	139/619 (22%)
SLY1	NP_010475.1	SEC1	11..661	CDD:227487	141/628 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810