Protein Alignment Vps45 and SEC1

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_010448.1
• Gene: SEC1 / 851742
• SGDID: S000002571
• Length: 724
• Species: Saccharomyces cerevisiae
• Alignment Length: 664
• Identity: 140/664 - (21%)
• Similarity: 253/664 - (38%)
• Gaps: 177/664 - (26%)

  Fly    17 ESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDS----GRSNERLKYLKCIVFIRPTK 77
            |:...:|.:::||...:|:|..|.....|...|...:.:||    |:|:     ::.|..:.|||
Yeast    20 ETKNNLKFLIIDKTVETILSYLFLTPQELLNNVTSVDLIDSPTRKGQSS-----IEAIYILEPTK 79

  Fly    78 QNIQLLANE--LRNPKYSAYYIYF----SNIIPR--TDIKYLAECDESESVRE----VKE-LYAD 129
            .||..:..:  :|.|||...:|.|    :|.|.:  ...:|:|:..||....|    ||| .:.:
Yeast    80 YNINCIDADFMVRPPKYRRCHIRFLPGLTNPIFQFFQSKRYIAQNLESFKPIELGFFVKESQFFE 144

  Fly   130 YLCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAK---- 190
            .|.:..:|......||.|   .:|..:.:.:..:.::.:.....|::||...:...:..|:
Yeast   145 TLQMEHSLQVFFNNNCKA---LIPTNVRKIVGSLVSLCVITGEYPIVRYSVSNPVEEEDARNGNA 206

  Fly   191 -LIYEQITKE-SSLFDF------RSNMDGAAPP--------LLLVLDRRDDPVTPLLHQWTYQAM 239
             :....:|:. ::.|..      |:|.|  .||        :|::.||..||..|:||.::||||
Yeast   207 VVNANSLTRSIANAFQIAIDTYARNNPD--FPPQNTERPRSILIITDRTLDPFAPILHDFSYQAM 269

  Fly   240 VHELLHIKNNRLDLSNCPNVPKDFKELVLSGDQD-------DFYGNN---------MYAN-YGEI 287
            .::|:...:.:.|:.:       :.....:|:|:       |.|..:         |.|| |  |
Yeast   270 AYDLVANVDTQKDIYH-------YSAENEAGEQEEKVSKLVDLYDPDWIDLKHQHIMDANEY--I 325

  Fly   288 GSTIKQLMEEFQRKAN----DHKKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKR 348
            ...||:|:.:     |    |...|::..|:.:.:.....|.:....:..|..::.|....:.:|
Yeast   326 QGRIKELIAK-----NPLLVDRSNVKNTTDLLSVVAHLKDFDEERRRLILHKTLVDECLGENAER 385

  Fly   349 NLFEVSELEQEIA-CKAEHSAQLQRIKKLIAD-------ERVSIDDALKLVALYALRYERHANCD 405
            .|.::|.:||.:: ...:.|.  ::||.:|.|       :..:|.|.|:.:..|||
Yeast   386 KLADISAIEQNLSGFGMDFSG--EKIKHIIDDLLPALAMKEPTILDKLRYIIAYAL--------- 439

  Fly   406 TSGLLQIIKTRGGRAAIVP----SLIEYAG-TH-----------VRQGDLFNMVRITDAVK---- 450
                     .|||   |:.    .|:.:.| ||           .|..||.:...|.|..|
Yeast   440 ---------FRGG---IIELDFIKLLNFIGVTHEHENFQQYLKIFRNYDLIDFKLIKDKPKDKPF 492

  Fly   451 ----LTRNLI---------KGLKGVENVFT-----------QHTPLLKETLEDVFKGREL----- 486
                ....|:         :.:..|.|:.:           |:.|.||:...::....|.
Yeast   493 QKEWFHDTLVNDPNIYHTSRFVPAVGNILSKVIANPLLLSEQYFPYLKDKPIELLNEEEFQAGLA 557

  Fly   487 -----------DPLFPA---INSELVPFRRPPQEVVVFIIGGATYEEALAVH-QLNNAGYKVILG 536
                       :|...|   ..|..:....|.|....::|||.:..|..|.: |.|.....:.:|
Yeast   558 NTSANSSSSLRNPRHKAAWTTKSSNIKKNIPRQRFFYYVIGGISIPEIKAAYDQSNLKNRDIFIG 622

  Fly   537 GTTIHNSQSFIQEV 550
            ...|.....|:.||
Yeast   623 SDEILTPTKFLDEV 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	136/649 (21%)
SEC1	NP_010448.1	SEC1	1..644	CDD:227487	140/664 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810