Protein Alignment Vps45 and VPS33

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_013500.3
• Gene: VPS33 / 851112
• SGDID: S000004388
• Length: 691
• Species: Saccharomyces cerevisiae
• Alignment Length: 679
• Identity: 144/679 - (21%)
• Similarity: 249/679 - (36%)
• Gaps: 188/679 - (27%)

  Fly    16 SESGPGMKIILLDKETTSIISMAFS---QSDML-----QREVYLFERLDSGRSNERLKYLKCIVF 72
            ::|.|..||.|||.:.:..:..|..   |.|::     :..:.|..:|........|..|. |::
Yeast    52 TQSTPVRKITLLDDQLSDDLPSALGSVPQMDLIFLIDVRTSLRLPPQLLDAAQKHNLSSLH-IIY 115

  Fly    73 IR--PTKQN-------------------------IQLLANELRNPKYSAYYIYFSNIIPRTDIKY 110
            .|  |:.||                         |:....||.|    .|.:|..:::|...|
Yeast   116 CRWKPSFQNTLEDTEQWQKDGFDLNSKKTHFPNVIESQLKELSN----EYTLYPWDLLPFPQI-- 174

  Fly   111 LAECDESESVREVKELYADYLCVN---PNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKL 172
                  .|:|.....|| :...||   |||.||.    .|..:.|.|.:..|:|.:.....|:..
Yeast   175 ------DENVLLTHSLY-NMENVNMYYPNLRSLQ----SATESILVDDMVNSLQSLIFETNSIIT 228

  Fly   173 NPVIRYRAGSQAAQLLAKLIYEQITK-----ESSLFDFRSN----MDGAAPPLLLVLDRRDDPVT 228
            |.|.......:.:.||.|.|.|..|:     :.:|:..|:|    ||      |::|:|..||:|
Yeast   229 NVVSIGNLSKRCSHLLKKRIDEHQTENDLFIKGTLYGERTNCGLEMD------LIILERNTDPIT 287

  Fly   229 PLLHQWTYQAMVHELLHIKNNRLDLSNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQ 293
            |||.|.||..::.:|... |:.:.:..        |::..:..:|..:.:..:.|:|.||..:.:
Yeast   288 PLLTQLTYAGILDDLYEF-NSGIKIKE--------KDMNFNYKEDKIWNDLKFLNFGSIGPQLNK 343

  Fly   294 LMEEFQRKANDHKKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGE-LSALSNKR--NLFEVSE 355
            |.:|.|.:.:...|.||:.::|.|::|....::....::.|..:..: |..:..:.  :..::.|
Yeast   344 LAKELQTQYDTRHKAESVHEIKEFVDSLGSLQQRQAFLKNHTTLSSDVLKVVETEEYGSFNKILE 408

  Fly   356 LEQEIACKAEHSAQLQR-IKKLIADERVSIDDALKLVALYAL----------RYERHANCDTSGL 409
            ||.||......:..::. |.:|.....|.....|:|:.|.:|          .|.|....|:.|:
Yeast   409 LELEILMGNTLNNDIEDIILELQYQYEVDQKKILRLICLLSLCKNSLREKDYEYLRTFMIDSWGI 473

  Fly   410 -----------LQIIKTRGGRAAI-----------------------VPSLIEYAGTHV-RQGDL 439
                       |....::.|:..:                       ||...|:|...: .:.|.
Yeast   474 EKCFQLESLAELGFFTSKTGKTDLHITTSKSTRLQKEYRYISQWFNTVPIEDEHAADKITNENDD 538

  Fly   440 FNMVRI--TDAVKLTRNLIKGLKGVENVFTQHT----------PLLKETLEDVFKGRELDPLF-- 490
            |:....  :..|.||..|::.|.....:|..::          |.:.:| ||:     ::.|:
Yeast   539 FSEATFAYSGVVPLTMRLVQMLYDRSILFHNYSSQQPFILSREPRVSQT-EDL-----IEQLYGD 597

  Fly   491 -PAINSEL-VP-------------------------FRRPPQEVVVFIIGGATYEE-ALAVHQLN 527
             .||...: ||                         |.......:|..:||.|..| |:..|...
Yeast   598 SHAIEESIWVPGTITKKINASIKSNNRRSIDGSNGTFHAAEDIALVVFLGGVTMGEIAIMKHLQK 662

  Fly   528 NAGYKVI-----------LGGTTIHNSQS 545
            ..|.|.|           :.||.|.||.|
Yeast   663 ILGKKGINKRFIIIADGLINGTRIMNSIS 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	139/668 (21%)
VPS33	NP_013500.3	SEC1	14..651	CDD:227487	131/637 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810