Protein Alignment Vps45 and Vps33a

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_084205.3
• Gene: Vps33a / 77573
• MGIID: 1924823
• Length: 598
• Species: Mus musculus
• Alignment Length: 609
• Identity: 125/609 - (20%)
• Similarity: 246/609 - (40%)
• Gaps: 101/609 - (16%)

  Fly     7 IKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIV 71
            ::.:::| |:    |.|.|:.|:..|....:....|.:.:.||.....|...|.  ....:|.|:
Mouse    23 LREFLDK-CA----GSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTLKGSRL--PAADVKNII 80

  Fly    72 F-IRPTKQNIQLLANEL-----RNPKYSAYYIYFSNIIPRTDI---KYLAECDESESVREVKELY 127
            | :||..:.:.::|..:     |.|... ::|.|   :||..:   :.|.:.....|....:|..
Mouse    81 FLVRPRLELMDIIAENVLSEDRRGPTRD-FHILF---VPRRSLLCEQRLKDLGVLGSFIHREEYS 141

  Fly   128 ADYLCVNPNLFSL----GIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVI--RYRAGSQAAQ 186
            .|.:..:.:|.|:    ....|.  |.....:|..:.:|:..:.......|.|  :.....|.|.
Mouse   142 LDLIPFDGDLLSMESEGAFKECY--LEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVAN 204

  Fly   187 LLAKLIYEQITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRL 251
            ::.::..|....::|:|....|        ||:|||..|.:|||..|.||:.::.|:..|:|:.:
Mouse   205 MMVRMKREFTGSQNSVFPVFDN--------LLLLDRNVDLLTPLASQLTYEGLIDEIYGIQNSYV 261

  Fly   252 DL-------------SNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRKAN 303
            .|             |...::|.:.|:|.|: ..::.|......|:..:||.:.:..:.......
Mouse   262 KLPPEKFAPKKQGGGSGGKDLPTEAKKLQLN-SAEELYAEIRDKNFNAVGSVLSKKAKIISAAFE 325

  Fly   304 DHKKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSA 368
            :....:::.::|.|:...|..:...|::..|..:...:..::...:.|:...:|||.....:...
Mouse   326 ERHNAKTVGEIKQFVSQLPHMQAARGSLANHTSIAELIKDVTTSEDFFDKLTVEQEFMSGIDTDK 390

  Fly   369 QLQRIKKLIADERVSIDDALKLVALYALRYERHANCDTSGLLQ---------IIKTRGGRAAIVP 424
            ....|:..||.:...| ..|:||.|.::       |: |||.|         |::|.|....:..
Mouse   391 VNSYIEDCIAQKHPLI-KVLRLVCLQSV-------CN-SGLKQKVLDYYRREILQTYGYEHILTL 446

  Fly   425 SLIEYAG-THVRQGDLFNMVRITDAVKLTRNLI--KGLKGVENVFTQHTPL-------------- 472
            :.:|.|| ...:.|...|...|...::|..:.:  :....:..|::.:.||
Mouse   447 NNLEKAGLLKAQTGGRNNYPTIRKTLRLWMDDVNEQNPTDISYVYSGYAPLSVRLAQLLSRPGWR 511

  Fly   473 -LKETLEDVFKG---RELDPLFPAINSELVPFRRPPQE---VVVFIIGGATYEEALAVH---QLN 527
             ::|.|. :..|   .|..||...:..     :|.|.|   .:||.:||.|:.|..|:.   ||.
Mouse   512 SIEEVLR-ILPGPHFEERQPLPTGLQK-----KRQPGENRVTLVFFLGGVTFAEIAALRFLSQLE 570

  Fly   528 NAGYKVILGGTTIHNSQSFIQEVV 551
            :.|.:.::..|.:.|..|:|:.::
Mouse   571 DGGTEYVIATTKLMNGNSWIEALM 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	119/583 (20%)
Vps33a	NP_084205.3	Sec1	34..586	CDD:279352	119/583 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810