Protein Alignment Vps45 and STXBP2

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001258963.1
• Gene: STXBP2 / 6813
• HGNCID: 11445
• Length: 604
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 146/634 - (23%)
• Similarity: 274/634 - (43%)
• Gaps: 130/634 - (20%)

  Fly     5 SGIKLYI-EKMCS------ESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNE 62
            ||:|..: ||:.|      :.....|::::|..:..|:|.....||:|...:.:.|  |..:..|
Human     4 SGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVE--DINKRRE 66

  Fly    63 RLKYLKCIVFIRPTK-----------QNIQLLANELRNP---KYSAYYIYFSNIIPRTDIKYLAE 113
            .:..|:.|..:.||:           |::|.|..:.:..   .|.|.:|:|::..|......|..
Human    67 PIPSLEAIYLLSPTEKAQAQRVIHLPQSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 131

  Fly   114 CDESESVREVKELYADYLCVNPNLFSLGIPNCMANLNWLP---DALNRSM----QGITAVLLSLK 171
            ...::.|:.:||::..:|.....:|||..|:...|| :.|   :...|.:    |.|..:..:|:
Human   132 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNL-YCPFRAEERTRQLEVLAQQIATLCATLQ 195

  Fly   172 LNPVIRYRAGSQ-AAQL----LAKLIYEQITKESSLFDFRSNMDGAAP----PLLLVLDRRDDPV 227
            ..|.||||.|.: .|||    ||||         :.|...:...|..|    ..||::||..|||
Human   196 EYPAIRYRKGPEDTAQLAHAVLAKL---------NAFKADTPSLGEGPEKTRSQLLIMDRAADPV 251

  Fly   228 TPLLHQWTYQAMVHELLHIKNN--RLDLSNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGST 290
            :||||:.|:|||.::||.|:.:  |.:.:   .:.:..::.||..:.||.:....:.:..::...
Human   252 SPLLHELTFQAMAYDLLDIEQDTYRYETT---GLSEAREKAVLLDEDDDLWVELRHMHIADVSKK 313

  Fly   291 IKQLMEEF---QRKANDHKKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFE 352
            :.:|:..|   :|...|.   .:|.|:...::..||::|.......||.:..:... ..|.::.:
Human   314 VTELLRTFCESKRLTTDK---ANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMK-HFKGSVEK 374

  Fly   353 VSELEQEIACKAEHSAQLQRIK---KLIA----DERVSIDDALKLVALYAL-----------RYE 399
            :..:||::|..::  |:.::||   |||.    |..|...|.::::.||.|           :..
Human   375 LCSVEQDLAMGSD--AEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKLI 437

  Fly   400 RHANCDT-SGLLQIIKTRGGRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKLTRNLIKGLKGVE 463
            :|||... |.|::.::..||.......    :||..|   |....|:....:|:|
Human   438 QHANVQAHSSLIRNLEQLGGTVTNPGG----SGTSSR---LEPRERMEPTYQLSR---------- 485

  Fly   464 NVFTQHTPLLKETLEDVFKGRELDPLFPAI----------------------NSELVPFRRPPQE 506
                 .||::|:.:||..:.|....|:|.:                      |...:..|..|:
Human   486 -----WTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPR- 544

  Fly   507 VVVFIIGGATYEEALAVHQLNNA---GYKVILGGTTIHNSQSFIQEVVA 552
            ::|:::||....|..|.:::..|   .::|::|.:.|.....|:.::.|
Human   545 LIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKA 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	138/598 (23%)
STXBP2	NP_001258963.1	Sec1	29..584	CDD:279352	138/598 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..477		6/28 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810