Protein Alignment Vps45 and VPS33A

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_075067.2
• Gene: VPS33A / 65082
• HGNCID: 18179
• Length: 596
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 125/609 - (20%)
• Similarity: 249/609 - (40%)
• Gaps: 103/609 - (16%)

  Fly     7 IKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERL---KYLK 68
            ::.:::| |:    |.|.|:.|:..|....:....|.:.:.||   |::.:.:.| ||   ....
Human    23 LREFLDK-CA----GSKAIVWDEYLTGPFGLIAQYSLLKEHEV---EKMFTLKGN-RLPAADVKN 78

  Fly    69 CIVFIRPTKQNIQLLANEL-----RNPKYSAYYIYFSNIIPRTDI---KYLAECDESESVREVKE 125
            .|.|:||..:.:.::|..:     |.|... ::|.|   :||..:   :.|.:.....|....:|
Human    79 IIFFVRPRLELMDIIAENVLSEDRRGPTRD-FHILF---VPRRSLLCEQRLKDLGVLGSFIHREE 139

  Fly   126 LYADYLCVNPNLFSL----GIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVI--RYRAGSQA 184
            ...|.:..:.:|.|:    ....|.  |.....:|..:.:|:..:.......|.|  :.....|.
Human   140 YSLDLIPFDGDLLSMESEGAFKECY--LEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQV 202

  Fly   185 AQLLAKLIYEQITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNN 249
            |.::.::..|....::|:|....|        ||:|||..|.:|||..|.||:.::.|:..|:|:
Human   203 ANMMIRMKREFTGSQNSIFPVFDN--------LLLLDRNVDLLTPLATQLTYEGLIDEIYGIQNS 259

  Fly   250 RLDL-----------SNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRKAN 303
            .:.|           ....::|.:.|:|.|: ..::.|......|:..:||.:.:..:.......
Human   260 YVKLPPEKFAPKKQGDGGKDLPTEAKKLQLN-SAEELYAEIRDKNFNAVGSVLSKKAKIISAAFE 323

  Fly   304 DHKKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSA 368
            :....:::.::|.|:...|..:...|::..|..:...:..::...:.|:...:|||.....:...
Human   324 ERHNAKTVGEIKQFVSQLPHMQAARGSLANHTSIAELIKDVTTSEDFFDKLTVEQEFMSGIDTDK 388

  Fly   369 QLQRIKKLIADERVSIDDALKLVALYALRYERHANCDTSGLLQ---------IIKTRGGRAAIVP 424
            ....|:..|| ::.|:...|:||.|.::       |: |||.|         |::|.|....:..
Human   389 VNNYIEDCIA-QKHSLIKVLRLVCLQSV-------CN-SGLKQKVLDYYKREILQTYGYEHILTL 444

  Fly   425 SLIEYAGTHVRQ-GDLFNMVRITDAVKLTRNLI--KGLKGVENVFTQHTPL-------------- 472
            ..:|.||....| |...|...|...::|..:.:  :....:..|::.:.||
Human   445 HNLEKAGLLKPQTGGRNNYPTIRKTLRLWMDDVNEQNPTDISYVYSGYAPLSVRLAQLLSRPGWR 509

  Fly   473 -LKETLEDVFKG---RELDPLFPAINSELVPFRRPPQE---VVVFIIGGATYEEALAVH---QLN 527
             ::|.|. :..|   .|..||...:..     :|.|.|   .::|.:||.|:.|..|:.   ||.
Human   510 SIEEVLR-ILPGPHFEERQPLPTGLQK-----KRQPGENRVTLIFFLGGVTFAEIAALRFLSQLE 568

  Fly   528 NAGYKVILGGTTIHNSQSFIQEVV 551
            :.|.:.::..|.:.|..|:|:.::
Human   569 DGGTEYVIATTKLMNGTSWIEALM 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	119/583 (20%)
VPS33A	NP_075067.2	Sec1	34..584	CDD:395791	119/583 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810