DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps45 and vps45

DIOPT Version :9

Sequence 1:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001243585.1	Gene:	vps45 / 561653	ZFINID:	ZDB-GENE-060503-526	Length:	568	Species:	Danio rerio

Alignment Length:	557	Identity:	293/557 - (52%)
Similarity:	403/557 - (72%)	Gaps:	15/557 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65
            ||:...:|.||.||...||||||::|:|||||||:|:.::||::||:|||||||:|| ::.:.:|
Zfish     1 MNVTLAVKQYISKMIESSGPGMKVLLMDKETTSIVSVVYTQSEILQKEVYLFERIDS-QNRDNMK 64

  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130
            :||.|.|:||||:|::.|..|||.||||.|:|||||:|.::::|.|||.||.|.|.||:|.|.|:
Zfish    65 HLKAICFLRPTKENVEHLIQELRRPKYSVYFIYFSNVISKSEVKALAEADEQEVVAEVQEFYGDF 129

  Fly   131 LCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQ 195
            :.|||:||||.:.......:|.|..|.|..||:|:||||||..|:|||:..|..::.||:.:.:.
Zfish   130 IAVNPHLFSLNLQGVSRGRSWEPSVLPRVTQGLTSVLLSLKKCPMIRYQLSSDMSKRLAESVKQI 194

  Fly   196 ITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVP 260
            ||||..|||||..   ..|||||:|||.||.:||||:||||||||||||.:.|||:|||..|.:.
Zfish   195 ITKEYELFDFRKT---EVPPLLLILDRSDDAITPLLNQWTYQAMVHELLGLNNNRIDLSRVPGIS 256

  Fly   261 KDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQ-RKANDHKKVESIADMKNFIESYPQF 324
            ||.:|:|||.:.|:||.||:|.|:||||:.||.|||:|| :|..|.:|:|||:|||.|:|:||||
Zfish   257 KDLREVVLSAENDEFYANNLYLNFGEIGTNIKNLMEDFQKKKPKDQQKLESISDMKAFVENYPQF 321

  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389
            |||||||.||:.|:||||.|.::|.|.||||:|||:||:.:||...|.:::|:...|:|..||::
Zfish   322 KKMSGTVSKHVTVVGELSRLVSERQLMEVSEVEQELACQNDHSNAQQMLRRLLQSPRLSEIDAVR 386

  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRG---GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKL 451
            ||.|||||||:|::.....|::.:..:|   ....:|.:::||.|..:|..||   :..||||.:
Zfish   387 LVMLYALRYEKHSSSILPSLMEELNRKGVSERHRKMVHAVVEYGGKRIRGSDL---ITPTDAVSI 448

  Fly   452 TRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGAT 516
            |:...|||||||||:|||.|||.:||:.:.|||..|..||.:...  ..|..||:::||||||||
Zfish   449 TKQFFKGLKGVENVYTQHQPLLHDTLDQLIKGRLKDSQFPYLGPS--SLRDRPQDIIVFIIGGAT 511

  Fly   517 YEEALAVHQLNNA--GYKVILGGTTIHNSQSFIQEVV 551
            |||||.|:.||..  |.:::||||.|||::||::||:
Zfish   512 YEEALTVYNLNRTMPGVRIVLGGTHIHNTKSFLEEVM 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	276/525 (53%)
vps45	NP_001243585.1	Sec1	23..539	CDD:279352	275/524 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592693
Domainoid	1	1.000	556	1.000	Domainoid score	I239
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5250
Inparanoid	1	1.050	583	1.000	Inparanoid score	I973
OMA	1	1.010	-	-		QHG53693
OrthoDB	1	1.010	-	-		D311758at33208
OrthoFinder	1	1.000	-	-		FOG0005111
OrthoInspector	1	1.000	-	-		oto40558
orthoMCL	1	0.900	-	-		OOG6_101522
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1689
SonicParanoid	1	1.000	-	-		X3630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800