DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps45 and Scfd1

DIOPT Version :9

Sequence 1:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_062237.1	Gene:	Scfd1 / 54350	RGDID:	619828	Length:	637	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	143/622 - (22%)
Similarity:	268/622 - (43%)	Gaps:	109/622 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIVFIRPTKQNI 80
            |...|..|:::.|:....|||...|..::....:.|...|.|.|  :.::.:..:.|:.||::||
  Rat    32 SPGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDR--DPIRDVPAVYFVMPTEENI 94

  Fly    81 QLLANELRNPKYSAYYIYFSNIIPRTDIKYLAE----CDESESVREVKELYADYLCVNPNLFSLG 141
            ..|..:|||..|.:||:.|.:.|.|:.::.:|.    .:....|.:|.:.|.:::.:..::|.|
  Rat    95 DRLCQDLRNQLYESYYLNFISAISRSKLEDIANAALAANAVTQVAKVFDQYLNFITLEEDMFVL- 158

  Fly   142 IPNCMANLNWL-------PDALNRSMQGITAVL--------LSLKLNPVIRYRAGSQAAQLLAKL 191
               |..|...:       ||..:..|:.:...:        ::|...|:||...|:.|..:..||
  Rat   159 ---CNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKL 220

  Fly   192 IYEQITKESSLFDFRSNMDGAAP----------PLLLVLDRRDDPVTPLLHQWTYQAMVHELLHI 246
              ::..:| :|.|.|:::....|          |||:::||..|..|||.|.|||||:||::|..
  Rat   221 --DKKLRE-NLRDARNSLFTGDPLGTGQFSFQRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDF 282

  Fly   247 KNNRLDL------SNCPNVPKDFKELVLSGD---QDDFYGNNMYANYGEIGSTIKQLMEEFQRKA 302
            ..||::|      .|.|...:..::...|.|   .|.|:..:..:.:.|:..:::|.:|.::.:.
  Rat   283 HLNRVNLEESTGVENSPTGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQE 347

  Fly   303 NDHKKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVS------------- 354
            ::.|:::||..::.  |.......:|....|....:..|..|..|:.|.::.
  Rat   348 DEVKRLKSIMGLEG--EDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKA 410

  Fly   355 -------ELEQEIACKAEHSAQLQRIKKLIAD-ERVSIDDALKLVALYAL------------RYE 399
                   |.|::|..|......|..:   |:| :..:.:|.::|..:|.:            :|:
  Rat   411 RKLDVYFEYEEKIMSKTTLDKSLLDV---ISDPDAGTPEDKMRLFLIYYISAQQAPSEVDLEQYK 472

  Fly   400 R---HANCDTSGLLQIIKTRGGRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKLTRNLIKGLKG 461
            :   .|.|:.|. ||.||.....|.:..:...|..|..:...|.:.|..|.:..:       ::|
  Rat   473 KALTDAGCNLSP-LQYIKQWKAFAKMASTPASYGNTTTKPMGLLSRVMNTGSQFV-------MEG 529

  Fly   462 VENVFTQH-----TPLLKETLE-----DVFKGRELDPLFPAINSELVPFRRPP-QEVVVFIIGGA 515
            |:|:..:.     |.:|...:|     :....|..||.....|...||..:.| ||.:||::||.
  Rat   530 VKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRSNDSSVPRNKSPFQEAIVFVVGGG 594

  Fly   516 TYEE--ALAVHQLNNAGYKVILGGTTIHNSQSFIQEV 550
            .|.|  .|..:.....|..::.|.:.|.|:..||:::
  Rat   595 NYIEYQNLVDYIKGKQGKHILYGCSEIFNATQFIKQL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	138/606 (23%)
Scfd1	NP_062237.1	Sec1	39..457	CDD:279352	99/431 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810