Protein Alignment Vps45 and vps33b

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001014370.1
• Gene: vps33b / 541534
• ZFINID: ZDB-GENE-050327-73
• Length: 617
• Species: Danio rerio
• Alignment Length: 646
• Identity: 139/646 - (21%)
• Similarity: 249/646 - (38%)
• Gaps: 174/646 - (26%)

  Fly    17 ESGPGMKIILLDKETTSIISMAFSQSDMLQREV---YLFERLDSGRSNERLKYLKCIVFIRPTKQ 78
            |..||.|.:.:|.:..|.:....:.:.:.|.||   |..|......|:::|.:|     |||..|
Zfish    31 EQLPGKKDLFIDADLMSPLDRIANVTILKQHEVDKLYKVELKPIVSSSDQLCFL-----IRPRIQ 90

  Fly    79 NIQLLANELRNPK----YSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADYLCVNPNLFS 139
            .::.:::.:.:.|    :..|.|.|      |..|:.| |   |:|.|.:.:|.|......|.:.
Zfish    91 TVKWISDLVNSDKVAGRFRRYKIIF------TPQKFYA-C---ETVLEEQGVYGDVTTDEWNFYI 145

  Fly   140 LGIPNCMANLNWLPD-----ALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLL----------- 188
            |.:.:.:.:|. ||:     .|....:.:|               .|..|..||
Zfish   146 LPLDDDILSLE-LPEFFRDNFLEGDQRWVT---------------TGGGALHLLQSVYGSFSKVY 194

  Fly   189 -----AKLIYEQITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKN 248
                 ||::||...:.....:.|:.....|.  :.::||..|.||||..|..|:.:|.::..||.
Zfish   195 GIGRCAKMVYESWRELMEEGEQRTRQPEFAK--VFLIDRDVDFVTPLCSQVVYEGLVDDIFRIKC 257

  Fly   249 NRLDLSNCPNVPKDFKEL-VLSGDQDDFYG---NNMYAN-YGEIGSTIKQLMEEFQRKANDHKKV 308
            :.::..  |:|....|.: |:...||..:.   |..::| :|.:....|.|     :.|.|.::.
Zfish   258 SSVEFG--PDVTSSDKSIKVMLNSQDKVFNEIRNEHFSNVFGFLSQKAKNL-----QTAYDKRRG 315

  Fly   309 ESIADMKNFIESYPQFKKMSGTVQKHLCV---IGELSALSNKRNLFEVSELEQEIACKAEHSAQL 370
            ..|..||.|:..     ::.|..|:|..:   ||...::..|:...:..||     .|.|||. |
Zfish   316 MDIQQMKAFVAD-----ELKGLKQEHRLLSLHIGASESIMKKKTKQDFQEL-----LKTEHSL-L 369

  Fly   371 Q--RIKKLIA------DERVSIDDALKLVALYAL---------------RYER---------HAN 403
            :  .|::.||      :.:||:.|:|:|:.|.::               :|.:         .||
Zfish   370 EGFEIRECIAYIEEHINRQVSMIDSLRLLCLLSITENGLLSKDYRSLKAQYLQSYGIEHLLTFAN 434

  Fly   404 CDTSGLLQ---------IIKTRGG-----------------------------RAAIVPSLIEYA 430
            ....|||:         :::::.|                             |.|:||...|..
Zfish   435 LRQLGLLEEQQTGETLTVMESKVGKLVNDKTAGKLTDAFSSLAKKSNFRALSKRLALVPKSGEEY 499

  Fly   431 GTHVRQ--GDLFNMVRITDAVKLTRNLIK--GLKGVENVFTQHTPLLKETLEDVFKGRELDPLFP 491
            ...|.:  ..:|:...|..:.||...:::  |..|:|.|    |.:|        .|::......
Zfish   500 DLRVPRDMAYIFSGAYIPLSCKLIEQVLERDGWTGLEEV----TRML--------NGQDFAVTGG 552

  Fly   492 AINSELVPFRRPPQEVVVFIIGGATYEEALAVHQL-NNAGYKVILGGTTIHNSQSFIQEVV 551
            :.:||........:.::|..:||.||.|..|:..| ...|.:.|:..|.|.||...::.::
Zfish   553 SSSSEARNKSNGQRIILVMFLGGCTYSEISALRFLGKERGCRFIVLTTAITNSGRLLEALL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	134/630 (21%)
vps33b	NP_001014370.1	Sec1	37..605	CDD:279352	134/630 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810