Protein Alignment Vps45 and Vps45

DIOPT Version :10

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_038869.1
• Gene: Vps45 / 22365
• MGIID: 891965
• Length: 570
• Species: Mus musculus
• Alignment Length: 570
• Identity: 309/570 - (54%)
• Similarity: 423/570 - (74%)
• Gaps: 20/570 - (3%)

  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65
            ||::..:|.||.||..:||||||::|:|||||.|:||.::||::||:|||||||:|| ::.|.:|
Mouse     1 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDS-QNREIMK 64

  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130
            :||.|.|:||||:|::.|..|||.||||.|:|||||:|.::|:|.|||.||.|.|.||:|.|.||
Mouse    65 HLKAICFLRPTKENVEYLIQELRRPKYSIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDY 129

  Fly   131 LCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQ 195
            :.|||:||||.|..|....||.|..|:|:.||:||:|||||..|:|||:..|:||:.|.:.:.:.
Mouse   130 IAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLGECVKQV 194

  Fly   196 ITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVP 260
            |:||..||:||..   ..|||||:|||.||.:||||:||||||||||||.|.|||:|||..|.:.
Mouse   195 ISKEYELFEFRRT---EVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGIS 256

  Fly   261 KDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRK-ANDHKKVESIADMKNFIESYPQF 324
            ||.:|:|||.:.|:||.||||.|:.||||.||.|||:||:| ..:.:|:|||||||.|:|:||||
Mouse   257 KDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKRPKEQQKLESIADMKAFVENYPQF 321

  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389
            |||||||.||:.|:||||.|.::|||.||||:|||:||:.:||:.||.:|:|:.:.:|:..||::
Mouse   322 KKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAVR 386

  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRG---GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKL 451
            ||.||||.||||::....||:..::::|   ....:|.:::||.|..||..|||:.   .|||.:
Mouse   387 LVMLYALHYERHSSNSLPGLIVDLRSKGVAEKYRKLVSAVVEYGGKRVRGSDLFSP---KDAVAI 448

  Fly   452 TRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGAT 516
            |:..:|||||||||:|||.|.|.|||:.:.|||..:.|:|.:....:  |..||:::||||||||
Mouse   449 TKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTL--RDRPQDIIVFIIGGAT 511

  Fly   517 YEEALAVHQLNNA--GYKVILGGTTIHNSQSFIQEVVAATSGIQFKHTKS 564
            |||||.|:.||..  |.:::||||||||::||::||:|  ||:   |::|
Mouse   512 YEEALTVYNLNRTTPGVRIVLGGTTIHNTKSFLEEVLA--SGL---HSRS 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..549	CDD:460020	290/531 (55%)
Vps45	NP_038869.1	Sec1	23..546	CDD:460020	288/528 (55%)