DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps45 and Vps45

DIOPT Version :9

Sequence 1:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_038869.1	Gene:	Vps45 / 22365	MGIID:	891965	Length:	570	Species:	Mus musculus

Alignment Length:	570	Identity:	309/570 - (54%)
Similarity:	423/570 - (74%)	Gaps:	20/570 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65
            ||::..:|.||.||..:||||||::|:|||||.|:||.::||::||:|||||||:|| ::.|.:|
Mouse     1 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDS-QNREIMK 64

  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130
            :||.|.|:||||:|::.|..|||.||||.|:|||||:|.::|:|.|||.||.|.|.||:|.|.||
Mouse    65 HLKAICFLRPTKENVEYLIQELRRPKYSIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDY 129

  Fly   131 LCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQ 195
            :.|||:||||.|..|....||.|..|:|:.||:||:|||||..|:|||:..|:||:.|.:.:.:.
Mouse   130 IAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLGECVKQV 194

  Fly   196 ITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVP 260
            |:||..||:||..   ..|||||:|||.||.:||||:||||||||||||.|.|||:|||..|.:.
Mouse   195 ISKEYELFEFRRT---EVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGIS 256

  Fly   261 KDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRK-ANDHKKVESIADMKNFIESYPQF 324
            ||.:|:|||.:.|:||.||||.|:.||||.||.|||:||:| ..:.:|:|||||||.|:|:||||
Mouse   257 KDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKRPKEQQKLESIADMKAFVENYPQF 321

  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389
            |||||||.||:.|:||||.|.::|||.||||:|||:||:.:||:.||.:|:|:.:.:|:..||::
Mouse   322 KKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAVR 386

  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRG---GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKL 451
            ||.||||.||||::....||:..::::|   ....:|.:::||.|..||..|||:.   .|||.:
Mouse   387 LVMLYALHYERHSSNSLPGLIVDLRSKGVAEKYRKLVSAVVEYGGKRVRGSDLFSP---KDAVAI 448

  Fly   452 TRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGAT 516
            |:..:|||||||||:|||.|.|.|||:.:.|||..:.|:|.:....:  |..||:::||||||||
Mouse   449 TKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTL--RDRPQDIIVFIIGGAT 511

  Fly   517 YEEALAVHQLNNA--GYKVILGGTTIHNSQSFIQEVVAATSGIQFKHTKS 564
            |||||.|:.||..  |.:::||||||||::||::||:|  ||:   |::|
Mouse   512 YEEALTVYNLNRTTPGVRIVLGGTTIHNTKSFLEEVLA--SGL---HSRS 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	287/525 (55%)
Vps45	NP_038869.1	Sec1	23..539	CDD:279352	283/521 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847431
Domainoid	1	1.000	578	1.000	Domainoid score	I217
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5250
Inparanoid	1	1.050	608	1.000	Inparanoid score	I924
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53693
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005111
OrthoInspector	1	1.000	-	-		oto92049
orthoMCL	1	0.900	-	-		OOG6_101522
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1689
SonicParanoid	1	1.000	-	-		X3630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790