Protein Alignment Vps45 and Stxbp3

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_035634.1
• Gene: Stxbp3 / 20912
• MGIID: 107362
• Length: 592
• Species: Mus musculus
• Alignment Length: 612
• Identity: 160/612 - (26%)
• Similarity: 273/612 - (44%)
• Gaps: 120/612 - (19%)

  Fly     7 IKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIV 71
            ||..:...|.:.|. .||:|||:.||.::|.....:|:|:..:.:.|.:...|  |.::.:|.:.
Mouse    18 IKTAVFDDCRKEGE-WKIMLLDEFTTKLLSSCCKMTDLLEEGITVIENIYKNR--EPVRQMKALY 79

  Fly    72 FIRPTKQNIQLLANEL---RNPKYSAYYIYFSNIIPRTDI-KYLAECDESESVREVKELYADYLC 132
            ||.||.:::.....:.   ...||.|.||||::..|.:.. |..|.|  |:|:|..||:...::.
Mouse    80 FISPTPKSVDCFLRDFGSKSEKKYKAAYIYFTDFCPDSLFNKIKASC--SKSIRRCKEINISFIP 142

  Fly   133 VNPNLFSLGIPN----CMANLNWLPDALNRS---------MQGITAVLLSLKLNPVIRYRA---- 180
            ....:::|.:|:    |     :.||..|.|         .:.|..|..:|..||.:||::
Mouse   143 QESQVYTLDVPDAFYYC-----YSPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKPLD 202

  Fly   181 -GSQAAQLLAKLI--YEQITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHE 242
             .|:.|||:.|.:  |.:|       |.:..:.|.....||::||..|||:.:||:.|:|||.::
Mouse   203 NASKLAQLVEKKLEDYYKI-------DEKGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYD 260

  Fly   243 LLHIKNNRLDLSNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQ--RKANDH 305
            ||.|:|   |........|: ||.||..| ||.:....:.:...:...|.:||:|..  :||.:.
Mouse   261 LLPIEN---DTYKYKTDGKE-KEAVLEED-DDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEG 320

  Fly   306 KKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQL 370
            |  .|::.:...::..|.|:|.......|| .:.|......|.|:.::.:.||::|...:  |:.
Mouse   321 K--TSLSALTQLMKKMPHFRKQISKQVVHL-NLAEDCMNKFKLNIEKLCKTEQDLALGTD--AEG 380

  Fly   371 QRIKKLIADERVSIDDALKLVALYALRYERHANCDTSGLLQIIKTRGGRAAIVPSLIEYAGTHVR 435
            ||:|           |:: ||.|..|..:.|.|||        |.|    |::..:....||...
Mouse   381 QRVK-----------DSM-LVLLPVLLNKNHDNCD--------KIR----AVLLYIFGINGTTEE 421

  Fly   436 QGD-LFNMVRITDAVKLTRNL----------------IKGLKGVENVF--TQHTPLLKETLEDVF 481
            ..| |.:.|:|.|...:.||.                ::..:..|..|  ::.||.:|:.:||..
Mouse   422 NLDRLIHNVKIEDDSDMIRNWSHLGVPIVPPSQQAKPLRKDRSAEETFQLSRWTPFIKDIMEDAI 486

  Fly   482 KGRELD-------PLFPAI--NSELVPFRRPPQ------------EVVVFIIGGATYEEALAVHQ 525
            ..| ||       ...||:  .|..|..|:.|:            .:::|:|||.||.|....::
Mouse   487 DNR-LDSKEWPYCSRCPAVWNGSGAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYE 550

  Fly   526 LNNA--GYKVILGGTTIHNSQSFIQEV 550
            ::.|  ..:||:|.|.|...:..:.::
Mouse   551 VSQAHKSCEVIIGSTHILTPRKLLDDI 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	156/587 (27%)
Stxbp3	NP_035634.1	Mediates interaction with DOC2B. /evidence=ECO:0000269|PubMed:17548353	1..255		71/253 (28%)
		Sec1	33..570	CDD:395791	156/587 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810