Protein Alignment Vps45 and Stxbp1

DIOPT Version :9

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001107041.1
• Gene: Stxbp1 / 20910
• MGIID: 107363
• Length: 603
• Species: Mus musculus
• Alignment Length: 590
• Identity: 119/590 - (20%)
• Similarity: 255/590 - (43%)
• Gaps: 98/590 - (16%)

  Fly    23 KIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIVFIRPTKQNIQLLANEL 87
            |::::|:.:..::|.....:|::...:.:.|  |..:..|.|..|:.:..|.|:::::..|.::.
Mouse    29 KVLVVDQLSMRMLSSCCKMTDIMTEGITIVE--DINKRREPLPSLEAVYLITPSEKSVHSLISDF 91

  Fly    88 RNP---KYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADYLCVNPNLFSLGIPNCMANL 149
            ::|   ||.|.:::|::..|......|.:...::.::.:.|:...:|.....::||...:...:.
Mouse    92 KDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSF 156

  Fly   150 NWLP-------DALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQITKESSLFDFRS 207
             :.|       ..|.|..:.|..:..:||..|.:|||...:...|||:||.:::....:......
Mouse   157 -YSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMG 220

  Fly   208 NMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVPKDFKELVLSGDQ 272
            .....|...||:|||..||.:|:||:.|:|||.::||.|:|:..............||::|..|
Mouse   221 EGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDED- 284

  Fly   273 DDFYGNNMYANYGEIGSTIKQLMEEF--QRKANDHKKVESIADMKNFIESYPQFKKMSGTVQKHL 335
            ||.:....:.:..|:...:.:.:::|  .::.|..:|. ::.|:...::..||::|
Mouse   285 DDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKT-TMRDLSQMLKKMPQYQK--------- 339

  Fly   336 CVIGELSALSNKRNLFE------------VSELEQEIACKAEHSAQ-----LQRIKKLIADERVS 383
                |||..|...:|.|            :..:||::|...:...:     ::.|..::.|..||
Mouse   340 ----ELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVS 400

  Fly   384 IDDALKLVALYALRYERHANCDTSGLLQIIKTRGGRAAIVPSLIEYAGTHVRQGDLF-NMVR--- 444
            ..|.::::.||                 |....|.....:..||::|.......::. ||..
Mouse   401 TYDKIRIILLY-----------------IFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGV 448

  Fly   445 --ITDAVKLTRNLIKGLKGV-ENVF--TQHTPLLKETLEDVFKGRELDPLFPAI----------- 493
              :||:....|:..:..:.: |..:  ::.||::|:.:||..:.:.....:|.|
Mouse   449 PIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTT 513

  Fly   494 -----------NSELVPFRRPPQEVVVFIIGGATYEEALAVHQLN--NAGYKVILGGTTIHNSQS 545
                       |.....:|..|: :::||:||.:..|....:::.  |..::|::|.|.|.....
Mouse   514 AVSARYGHWHKNKAPGEYRSGPR-LIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPTK 577

  Fly   546 FIQEV 550
            |:.::
Mouse   578 FLMDL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	118/581 (20%)
Stxbp1	NP_001107041.1	Sec1	29..575	CDD:395791	118/581 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810