Protein Alignment Vps45 and vps-45

DIOPT Version :10

• Sequence 1: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_741714.1
• Gene: vps-45 / 180449
• WormBaseID: WBGene00016643
• Length: 547
• Species: Caenorhabditis elegans
• Alignment Length: 557
• Identity: 222/557 - (39%)
• Similarity: 350/557 - (62%)
• Gaps: 30/557 - (5%)

  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65
            |:|:...:..|:.|...:|..||::|:|.|||..:|.||:||:::|:|||:|:|:::..|:|.:|
 Worm     1 MDLVQSSRKLIQDMIQLAGSQMKLLLMDGETTPTVSCAFAQSEVMQKEVYIFDRIENKTSSENIK 65

  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130
            .|||:||:|||.:||:.|..||:.|::|.||:||:|.|.:.|:|.|||.|::|:||||:|::.|.
 Worm    66 NLKCVVFVRPTPKNIERLVKELQEPRFSQYYLYFTNTINKYDVKRLAEADKNETVREVQEVFLDG 130

  Fly   131 LCVNPNLFSLGIPNCM-ANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYE 194
            :.:..:||:|.:.:.. ::.....:|..|...||.|:||.||..|.:||:..|.:.:.:|..:.:
 Worm   131 VPIRKDLFTLNLTHIFDSSFTLKEEAAERIKCGIIALLLQLKKAPAVRYQKSSPSCKKVADDVAQ 195

  Fly   195 QITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNV 259
            .|.:|:.||:     :..|...||:::|..|.|||||:||||:||:||:|.:.|||...::
 Worm   196 FIRRENGLFE-----NSRADTTLLIIERSQDAVTPLLNQWTYEAMIHEMLTLTNNRCTCTD---- 251

  Fly   260 PKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRKANDHKKVESIADMKNFIESYPQF 324
                :.:|||...|:|:..|:.||:||||..||.|:.|||.|.:.:|.:|||.|||.|:|.||||
 Worm   252 ----QNIVLSELHDEFFARNITANFGEIGQNIKTLISEFQEKKHINKNLESIQDMKKFVEDYPQF 312

  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389
            ||:||||.||:.::||||.|..|.||..|||:||.|....:|...:..::.|:.:.:....|.::
 Worm   313 KKISGTVSKHVSLVGELSNLVQKHNLLGVSEVEQAIVSDGDHGKCINLVRGLLKNTKTREVDIIR 377

  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRGGRA-AIVPSLIEYAGTHVRQGDLFNMVRITDAVKLTR 453
            ||.|||||:|.....:.:.|:..::.:..:. ..|.:|::|.|...|..|||..   ...:.:|:
 Worm   378 LVLLYALRFENAPGNELNSLISQLRPQHPKIHQTVSTLLKYGGLSRRPADLFGG---ESTIDITK 439

  Fly   454 NLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGATYE 518
            ..|||||||||::|||:|.||..:|...:|| ||. :|.:::|....    ..::|||:||||||
 Worm   440 RFIKGLKGVENIYTQHSPYLKNMIESCQRGR-LDN-YPLLSNECDRM----DNIIVFIVGGATYE 498

  Fly   519 EALAVHQLNN------AGYKVILGGTTIHNSQSFIQE 549
            ||..|..||.      .|..|:|.|:::.|::||::|
 Worm   499 EAAYVRSLNEKRMQGYGGPAVVLAGSSMLNTKSFLEE 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..549	CDD:460020	215/533 (40%)
vps-45	NP_741714.1	Sec1	23..535	CDD:460020	215/533 (40%)