DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps45 and Stxbp3

DIOPT Version :9

Sequence 1:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_446089.1	Gene:	Stxbp3 / 114095	RGDID:	619968	Length:	593	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	160/612 - (26%)
Similarity:	269/612 - (43%)	Gaps:	120/612 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIV 71
            ||..:...|.:.|. .||:|||..||.::|.....:|:|:..|.:.|.:...|  |.::.:|.:.
  Rat    18 IKTTVFDDCRKEGE-WKIMLLDDFTTRLLSSCCKMTDLLEEGVTVIENIYKNR--EPVRQMKALY 79

  Fly    72 FIRPTKQNIQLLANEL---RNPKYSAYYIYFSNIIPRTDI-KYLAECDESESVREVKELYADYLC 132
            ||.||.:::.....:.   ...||.|.||||::..|.:.. |..|.|  |:|:|..||:...::.
  Rat    80 FISPTPKSVDCFLRDFGSKSEKKYKAAYIYFTDFCPDSLFNKIKASC--SKSIRRCKEINISFIP 142

  Fly   133 VNPNLFSLGIPN----CMANLNWLPDALNRS---------MQGITAVLLSLKLNPVIRYRA---- 180
            ....:::|.:|:    |     :.||..|..         .:.|..|..:|..||.:||::
  Rat   143 HESQVYTLDVPDAFYYC-----YSPDPSNAGRKEAVMEAMAEQIVTVCATLDENPGVRYKSKPLD 202

  Fly   181 -GSQAAQLLAKLI--YEQITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHE 242
             .|:.|||:.|.:  |.:|       |....:.|.....||::||..|||:.:||:.|:|||.::
  Rat   203 NASKLAQLVEKKLEDYYKI-------DENGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYD 260

  Fly   243 LLHIKNNRLDLSNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQ--RKANDH 305
            ||.|:.   |........|: ||.||..| ||.:....:.:...:...|.:||:|..  :||.:.
  Rat   261 LLPIEK---DTYKYKTDGKE-KEAVLEED-DDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEG 320

  Fly   306 KKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQL 370
            |  .|::.:...::..|.|:|.......|| .:.|......|.|:.::.:.||::|...:  |:.
  Rat   321 K--TSLSALTQLMKKMPHFRKQISKQVVHL-NLAEDCMNKFKLNIEKLCKTEQDLALGTD--AEG 380

  Fly   371 QRIKKLIADERVSIDDALKLVALYALRYERHANCDTSGLLQIIKTRGGRAAIVPSLIEYAGTHVR 435
            ||:|           |:: ||.|..|..:.|.|||        |.|    |::..:....||...
  Rat   381 QRVK-----------DSM-LVLLPVLLNKNHDNCD--------KIR----AVLLYIFGVNGTTEE 421

  Fly   436 QGD-LFNMVRITDAVKLTRNLIK-GL---------------KGVENVF--TQHTPLLKETLEDVF 481
            ..| |.:.|:|.|...:.||... |:               :..|..|  ::.||.:|:.:||..
  Rat   422 NLDRLIHNVKIEDDSDMIRNWSHLGVPIVPPSQQAKPPRKDRSAEETFQLSRWTPFIKDIMEDAI 486

  Fly   482 KGRELD-------PLFPAI--NSELVPFRRPPQ------------EVVVFIIGGATYEEALAVHQ 525
            ..| ||       ...||:  .|..|..|:.|:            .:::|:|||.||.|....::
  Rat   487 DNR-LDSKEWPYCSRCPAVWNGSGAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYE 550

  Fly   526 LNNA--GYKVILGGTTIHNSQSFIQEV 550
            ::.|  ..:||:|.|.|...:..:.::
  Rat   551 VSQAHKSCEVIIGSTHILTPRKLLDDI 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	156/587 (27%)
Stxbp3	NP_446089.1	Sec1	33..570	CDD:279352	156/587 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810