DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps45 and VPS45

DIOPT Version :9

Sequence 1:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_009190.2	Gene:	VPS45 / 11311	HGNCID:	14579	Length:	570	Species:	Homo sapiens

Alignment Length:	570	Identity:	308/570 - (54%)
Similarity:	421/570 - (73%)	Gaps:	20/570 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65
            ||::..:|.||.||..:||||||::|:|||||.|:||.::||::||:|||||||:|| ::.|.:|
Human     1 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDS-QNREIMK 64

  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130
            :||.|.|:||||:|:..:..|||.|||:.|:|||||:|.::|:|.|||.||.|.|.||:|.|.||
Human    65 HLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDY 129

  Fly   131 LCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQ 195
            :.|||:||||.|..|....||.|..|:|:.||:||:|||||..|:|||:..|:||:.||:.:.:.
Human   130 IAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQV 194

  Fly   196 ITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVP 260
            ||||..||:||..   ..|||||:|||.||.:||||:||||||||||||.|.|||:|||..|.:.
Human   195 ITKEYELFEFRRT---EVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGIS 256

  Fly   261 KDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQ-RKANDHKKVESIADMKNFIESYPQF 324
            ||.:|:|||.:.|:||.||||.|:.||||.||.|||:|| :|..:.:|:|||||||.|:|:||||
Human   257 KDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQF 321

  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389
            |||||||.||:.|:||||.|.::|||.||||:|||:||:.:||:.||.||:|:.:.:|:..||.:
Human   322 KKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNIKRLLQNPKVTEFDAAR 386

  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRG---GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKL 451
            ||.||||.||||::....||:..::.:|   ....:|.:::||.|..||..|||:.   .|||.:
Human   387 LVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSP---KDAVAI 448

  Fly   452 TRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGAT 516
            |:..:|||||||||:|||.|.|.|||:.:.|||..:.|:|.:....:  |..||:::||:|||||
Human   449 TKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTL--RDRPQDIIVFVIGGAT 511

  Fly   517 YEEALAVHQLNNA--GYKVILGGTTIHNSQSFIQEVVAATSGIQFKHTKS 564
            |||||.|:.||..  |.:::|||||:||::||::||:|  ||:   |::|
Human   512 YEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLA--SGL---HSRS 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	286/525 (54%)
VPS45	NP_009190.2	Sec1	23..539	CDD:307231	285/524 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157028
Domainoid	1	1.000	577	1.000	Domainoid score	I218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5250
Inparanoid	1	1.050	608	1.000	Inparanoid score	I930
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53693
OrthoDB	1	1.010	-	-		D311758at33208
OrthoFinder	1	1.000	-	-		FOG0005111
OrthoInspector	1	1.000	-	-		oto88478
orthoMCL	1	0.900	-	-		OOG6_101522
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1689
SonicParanoid	1	1.000	-	-		X3630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940