DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-like and Mbd4

DIOPT Version :9

Sequence 1:	NP_001262421.1	Gene:	MBD-like / 41151	FlyBaseID:	FBgn0027950	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_001059437.3	Gene:	Mbd4 / 680915	RGDID:	1585874	Length:	566	Species:	Rattus norvegicus

Alignment Length:	314	Identity:	68/314 - (21%)
Similarity:	101/314 - (32%)	Gaps:	121/314 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LPKGWQR-DEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTGKRAEG--------- 73
            :|.||:| .:.|.||.:|                    .:||| |:.||.|.:...
  Rat    78 VPCGWERVVKQRLSGKTA--------------------GRVDV-YFISPQGSKFRSKRSLANYLL 121

  Fly    74 -------KPQDIAIPDF--------QPGKMPHCALPSPSI----------------SLYRCSAMP 107
                   ||:|.   ||        .|| ..|.:|.:|:.                |.::...:|
  Rat   122 KTGETCLKPEDF---DFTVLSKGGINPG-YKHQSLSAPASQQPNEADISKLNLRTRSKWKTDVLP 182

  Fly   108 LPIASGGGNG----ATSGSAANALKRKFARSQGGNAAGAAGAAPPAATA------SSAATATAAS 162
            ||    |||.    :.|.|.:|:.:......:|...|.:..:..|....      :|..|.....
  Rat   183 LP----GGNSESPDSNSLSNSNSARLLLKEHKGIQDADSGKSRKPKIKVTVLKGIASQRTKQRCR 243

  Fly   163 ASPS-TANRQQQQIELSRALRTDVSLVPP--------------IRQTASI--------------- 197
            .||| :..|.::::...:...||..|||.              .|.|.|:
  Rat   244 KSPSDSTGRNRKRLCTVQKADTDSELVPQESRLHRTVCPADACARATVSLVREAKGLGEEKSPSS 308

  Fly   198 ---FKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEE 248
               |.|..:.|.|.......|....:..|||   |.|.|.  |.:|:   .|||
  Rat   309 DLRFTQVTSSITNKLYSTEAAGEATREATRE---QTFLES--EEIRS---KGEE 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-like	NP_001262421.1	MBD	13..98	CDD:279737	25/103 (24%)
		MBDa	172..241	CDD:293172	20/100 (20%)
		MBD_C	246..338	CDD:290755	3/3 (100%)
Mbd4	XP_001059437.3	MeCP2_MBD	77..149	CDD:238690	22/95 (23%)
Mbd4	XP_001059437.3	ENDO3c	436..>522	CDD:304925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810