DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-like and MBD3L4

DIOPT Version :9

Sequence 1:	NP_001262421.1	Gene:	MBD-like / 41151	FlyBaseID:	FBgn0027950	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001157891.1	Gene:	MBD3L4 / 653656	HGNCID:	37206	Length:	208	Species:	Homo sapiens

Alignment Length:	173	Identity:	46/173 - (26%)
Similarity:	86/173 - (49%)	Gaps:	5/173 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 ANRQQQQIELSRALRTDVS-LVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLF 231
            |.:::::|.:::|.|...: ...|:|.|:.||::|||.||:|..:..:.:...:|  .|||:||.
Human    26 ALQKKREIHMAKAHRRRAARSALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEH--LEKPQQLC 88

  Fly   232 WEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLT 296
            ..:||:.|:.|...||....:.|...:..:.|....:::.::.|..:.:......|:....|...
Human    89 AYRRLQALQPCSSQGEGSSPLHLESVLSILAPGTAGESLDRAGAERVRIPLEPTPGRFPAVAGGP 153

  Fly   297 KNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALK 339
            ...|....|  |.:...:::..|||:|..||..||.:|..||:
Human   154 TPGMGCQLP--PPLSGQLVTPADIRRQARRVKKARERLAKALQ 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-like	NP_001262421.1	MBD	13..98	CDD:279737
		MBDa	172..241	CDD:293172	23/69 (33%)
		MBD_C	246..338	CDD:290755	19/91 (21%)
MBD3L4	NP_001157891.1	MBDa	<48..97	CDD:293172	19/50 (38%)
MBD3L4	NP_001157891.1	MBD_C	103..193	CDD:290755	19/91 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700