DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-like and MBD3

DIOPT Version :9

Sequence 1:	NP_001262421.1	Gene:	MBD-like / 41151	FlyBaseID:	FBgn0027950	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001268382.1	Gene:	MBD3 / 53615	HGNCID:	6918	Length:	291	Species:	Homo sapiens

Alignment Length:	343	Identity:	109/343 - (31%)
Similarity:	161/343 - (46%)	Gaps:	113/343 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IERKRVDCSVLPKGWQRDEV-RKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTGKRAE 72
            :||||.:|..||:||:|:|| |:||.||.:.                    ||||| ||:||:..
Human     1 MERKRWECPALPQGWEREEVPRRSGLSAGHR--------------------DVFYY-SPSGKKFR 44

  Fly    73 GKPQ---------DIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALK 128
            .|||         |::..||:.|||                                      |.
Human    45 SKPQLARYLGGSMDLSTFDFRTGKM--------------------------------------LM 71

  Fly   129 RKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRAL--RTDVSLVPPI 191
            .|..:|                                   ||:.:.:.|..:  :.|::...|:
Human    72 SKMNKS-----------------------------------RQRVRYDSSNQVKGKPDLNTALPV 101

  Fly   192 RQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEEL-DDISLP 255
            ||||||||||||.|.||..:  |.|::|:... ::|:||||||:|..|.| .|..||| ..:.||
Human   102 RQTASIFKQPVTKITNHPSN--KVKSDPQKAV-DQPRQLFWEKKLSGLNA-FDIAEELVKTMDLP 162

  Fly   256 KTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDI 320
            |.::.|||...::|:|.::|:|||.....:.||.|  |.:.||...::|..|||..|.:::::||
Human   163 KGLQGVGPGCTDETLLSAIASALHTSTMPITGQLS--AAVEKNPGVWLNTTQPLCKAFMVTDEDI 225

  Fly   321 RKQEDRVGVARRKLQDAL 338
            ||||:.|...|::|::||
Human   226 RKQEELVQQVRKRLEEAL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-like	NP_001262421.1	MBD	13..98	CDD:279737	32/94 (34%)
		MBDa	172..241	CDD:293172	30/70 (43%)
		MBD_C	246..338	CDD:290755	35/92 (38%)
MBD3	NP_001268382.1	MeCP2_MBD	5..79	CDD:238690	35/167 (21%)
		MBDa	82..148	CDD:406868	30/68 (44%)
		MBD_C	153..243	CDD:404858	35/91 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..291
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147285
Domainoid	1	1.000	78	1.000	Domainoid score	I8796
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3955
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45529
OrthoDB	1	1.010	-	-		D1431783at2759
OrthoFinder	1	1.000	-	-		FOG0001638
OrthoInspector	1	1.000	-	-		otm40382
orthoMCL	1	0.900	-	-		OOG6_105834
Panther	1	1.100	-	-	O	PTHR12396
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5306
SonicParanoid	1	1.000	-	-		X1743
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800