DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-like and MBD1

DIOPT Version :9

Sequence 1:	NP_001262421.1	Gene:	MBD-like / 41151	FlyBaseID:	FBgn0027950	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001310871.1	Gene:	MBD1 / 4152	HGNCID:	6916	Length:	680	Species:	Homo sapiens

Alignment Length:	162	Identity:	42/162 - (25%)
Similarity:	61/162 - (37%)	Gaps:	47/162 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VDCSVLPKGWQRDEV-RKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTGKRAEGKPQ- 76
            :||..|..||:|.|| ||||::...:.:                     ||.||||.|...|.:
Human     6 LDCPALGPGWKRREVFRKSGATCGRSDT---------------------YYQSPTGDRIRSKVEL 49

  Fly    77 --------DIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALKRKFAR 133
                    |:.:.||:.|.:   ..|:|       .|.|:.:||    ......:..|..||  |
Human    50 TRYLGPACDLTLFDFKQGIL---CYPAP-------KAHPVAVAS----KKRKKPSRPAKTRK--R 98

  Fly   134 SQGGNAAGAAGAAPPAATASSAATATAASASP 165
            ..|..:......||...|.:...||.|:..:|
Human    99 QVGPQSGEVRKEAPRDETKADTDTAPASFPAP 130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-like	NP_001262421.1	MBD	13..98	CDD:279737	26/93 (28%)
		MBDa	172..241	CDD:293172
		MBD_C	246..338	CDD:290755
MBD1	NP_001310871.1	MBD	3..76	CDD:128673	26/100 (26%)
		zf-CXXC	168..215	CDD:251032
		zf-CXXC	217..262	CDD:251032
		zf-CXXC	356..402	CDD:251032
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147288
Domainoid	1	1.000	53	1.000	Domainoid score	I11351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1431783at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850