Protein Alignment MBD-like and Mecp2

DIOPT Version :10

• Sequence 1: NP_001262421.1
• Gene: MBD-like / 41151
• FlyBaseID: FBgn0027950
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001418483.1
• Gene: Mecp2 / 29386
• RGDID: 3075
• Length: 520
• Species: Rattus norvegicus
• Alignment Length: 432
• Identity: 83/432 - (19%)
• Similarity: 124/432 - (28%)
• Gaps: 167/432 - (38%)

  Fly    15 DCSVLPKGWQRD-EVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTGKRAEGKPQDI 78
            |...||:||.|. :.||||.||                    .|.|| |..:|.||....|.:.|
  Rat   124 DDPTLPEGWTRKLKQRKSGRSA--------------------GKYDV-YLINPQGKAFRSKVELI 167

  Fly    79 AI-----------PDF---------------QPGKMPHC----------------------ALPS 95
            |.           .||               :|.|.|..                      |..|
  Rat   168 AYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAAS 232

  Fly    96 PSISLYR---------CSAMPLPIASGG---GNGATSGSAANALKRKFARSQGGNAAGAA----- 143
            ..:.:.|         ...||...:.||   |.|||:.:....:||. .|.:...|...|
  Rat   233 EGVQVKRVLEKSPGKLLVKMPFQASPGGKGEGGGATTSAQVMVIKRP-GRKRKAEADPQAIPKKR 296

  Fly   144 GAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASI----FKQPVTV 204
            |..|.:..|::||.|...:...|:....|:.:...:..:|        |:|.||    ..:|:.|
  Rat   297 GRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKT--------RETVSIEVKEVVKPLLV 353

  Fly   205 I-----------------RNHKQDPAK-----AKNEPK------HGTREKPK------------- 228
            .                 |..|:...|     |.:.||      |...|.||
  Rat   354 STLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHAESPKAPMPLLPPPPPPE 418

  Fly   229 ------------------QLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVA 275
                              .:..|:::.|..:....|       .||......|.| ......:..
  Rat   419 PQSSEDPISPPEPQDLSSSICKEEKMPRAGSLESDG-------CPKEPAKTQPMV-AAAATTTTT 475

  Fly   276 TALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISE 317
            |...:.....|.....:.|:..::|...|.|:|:.....::|
  Rat   476 TTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-like	NP_001262421.1	MBD	9..101	CDD:396147	29/134 (22%)
		MBDa	171..241	CDD:465179	20/132 (15%)
		MBD_C	245..338	CDD:464072	13/73 (18%)
Mecp2	NP_001418483.1	MBD	120..197	CDD:128673	24/93 (26%)