DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-like and Mbd2

DIOPT Version :9

Sequence 1:	NP_001262421.1	Gene:	MBD-like / 41151	FlyBaseID:	FBgn0027950	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_034903.2	Gene:	Mbd2 / 17191	MGIID:	1333813	Length:	414	Species:	Mus musculus

Alignment Length:	344	Identity:	113/344 - (32%)
Similarity:	163/344 - (47%)	Gaps:	107/344 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSVTIERKRVDCSVLPKGWQRDEV-RKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTG 68
            |..|...||:||..||.||:::|| ||||.||                    .|.||:|: ||:|
Mouse   144 PRATESGKRMDCPALPPGWKKEEVIRKSGLSA--------------------GKSDVYYF-SPSG 187

  Fly    69 KRAEGKPQ---------DIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAA 124
            |:...|||         |::..||:.|||                 ||
Mouse   188 KKFRSKPQLARYLGNAVDLSSFDFRTGKM-----------------MP----------------- 218

  Fly   125 NALKRKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDVSLVP 189
            :.|::...|.:.                           .|...|:.          :.|::...
Mouse   219 SKLQKNKQRLRN---------------------------DPLNQNKG----------KPDLNTTL 246

  Fly   190 PIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISL 254
            ||||||||||||||...||..:  |.|::|:. ..|:|:||||||||:.|.|...:.:.:..:.|
Mouse   247 PIRQTASIFKQPVTKFTNHPSN--KVKSDPQR-MNEQPRQLFWEKRLQGLSASDVTEQIIKTMEL 308

  Fly   255 PKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDD 319
            ||.::.|||..|::|:|.:||:|||..:|.:.||.|  |.:.||...::|..|||..|.|::::|
Mouse   309 PKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVS--AAVEKNPAVWLNTSQPLCKAFIVTDED 371

  Fly   320 IRKQEDRVGVARRKLQDAL 338
            |||||:||...|:||::||
Mouse   372 IRKQEERVQQVRKKLEEAL 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-like	NP_001262421.1	MBD	13..98	CDD:279737	32/94 (34%)
		MBDa	172..241	CDD:293172	31/68 (46%)
		MBD_C	246..338	CDD:290755	38/91 (42%)
Mbd2	NP_034903.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..163		9/18 (50%)
		MeCP2_MBD	154..217	CDD:238690	31/100 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..244		7/80 (9%)
		MBDa	230..295	CDD:293172	33/104 (32%)
		MBD_C	300..390	CDD:290755	38/91 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837216
Domainoid	1	1.000	78	1.000	Domainoid score	I8757
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2918
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3945
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1431783at2759
OrthoFinder	1	1.000	-	-		FOG0001638
OrthoInspector	1	1.000	-	-		otm42452
orthoMCL	1	0.900	-	-		OOG6_105834
Panther	1	1.100	-	-	LDO	PTHR12396
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5306
SonicParanoid	1	1.000	-	-		X1743
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790