DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-like and mbd2

DIOPT Version :9

Sequence 1:	NP_001262421.1	Gene:	MBD-like / 41151	FlyBaseID:	FBgn0027950	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_012813111.2	Gene:	mbd2 / 100216281	XenbaseID:	XB-GENE-493776	Length:	265	Species:	Xenopus tropicalis

Alignment Length:	340	Identity:	113/340 - (33%)
Similarity:	164/340 - (48%)	Gaps:	107/340 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IERKRVDCSVLPKGWQRDEV-RKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTGKRAE 72
            :|::|::|..||.||:::|| ||||.||                    .|.||:|| ||.||:..
Frog     1 MEKRRMECPALPPGWKKEEVIRKSGLSA--------------------GKSDVYYY-SPNGKKFR 44

  Fly    73 GKPQ---------DIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALK 128
            .|||         |::..||:.|||                 ||                 :.|:
Frog    45 SKPQLARYLGNSVDLSSFDFRTGKM-----------------MP-----------------SKLQ 75

  Fly   129 RKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDVSLVPPIRQ 193
            :...|.:.                           .|...|:.          :.|::...||||
Frog    76 KNKQRLRN---------------------------DPLNQNKS----------KPDLNTTLPIRQ 103

  Fly   194 TASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTI 258
            ||||||||||.:.||..:  |.|::|:. ..|:|:|||||||||.|.|...:.:.:..:.|||.:
Frog   104 TASIFKQPVTKVTNHPSN--KVKSDPQR-VIEQPRQLFWEKRLEGLSASDVTEQVIKPMELPKGL 165

  Fly   259 RTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQ 323
            :.|||..||||:|.::|:|||..:|.:.||.|  |.:.||...::|..|||..|.::::||||||
Frog   166 QGVGPGNNEQTLLAAIASALHTSSAPITGQLS--AAVEKNPSVWLNTSQPLCKAFLVTDDDIRKQ 228

  Fly   324 EDRVGVARRKLQDAL 338
            |:||...|:||::||
Frog   229 EERVQNVRKKLEEAL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-like	NP_001262421.1	MBD	13..98	CDD:279737	32/94 (34%)
		MBDa	172..241	CDD:293172	32/68 (47%)
		MBD_C	246..338	CDD:290755	39/91 (43%)
mbd2	XP_012813111.2	MeCP2_MBD	7..70	CDD:238690	31/100 (31%)
		MBDa	82..148	CDD:406868	34/105 (32%)
		MBD_C	153..243	CDD:404858	39/91 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3797
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1431783at2759
OrthoFinder	1	1.000	-	-		FOG0001638
OrthoInspector	1	1.000	-	-		otm47554
Panther	1	1.100	-	-	LDO	PTHR12396
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5306
SonicParanoid	1	1.000	-	-		X1743
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190