Protein Alignment AP-1mu and AP4M1

DIOPT Version :10

• Sequence 1: NP_649906.1
• Gene: AP-1mu / 41150
• FlyBaseID: FBgn0024833
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001350600.1
• Gene: AP4M1 / 9179
• HGNCID: 574
• Length: 460
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 131/473 - (27%)
• Similarity: 228/473 - (48%)
• Gaps: 68/473 - (14%)

  Fly     4 SAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGL---ITPILQTAE--------TT 57
            |..|:|..||..||.:::|||:....|.:.|.     |:..||   .:|::....        ..
Human     3 SQFFILSSKGDPLIYKDFRGDSGGRDVAELFY-----RKLTGLPGDESPVVMVTSGGRRHHHGRH 62

  Fly    58 FAYIKTNNLYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLD 122
            |.:|:.:.||:|.||  ::||:...:...|.::|.:..:|...|.|.:|..|..::||||||:||
Human    63 FIHIRHSGLYLVVTT--SENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLD 125

  Fly   123 FGYPQTTDSKILQEYITQE------------------GHKLELQPRIPVAVTNAVSWRSEGIKYR 169
            :||.|||.:::|:.:|..|                  |.:.:.....|.:..:.....|...:.:
Human   126 YGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQ 190

  Fly   170 KNEVFLDVIESVNLLANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDK-VLFESTGRGKSKSV 233
            ||||||||:|.:::|..:||::|:.::.|.|:::.:|....|:|:||.:: .:.:|..||....:
Human   191 KNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGI 255

  Fly   234 ELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVK---PLIWIESVIERHAHSRVEY 295
            .:::|.||..|.|..||:.|.:...||.||..:|.|:|:..:.   |.....||.......|::.
Human   256 RVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQV 320

  Fly   296 MIKAKSQFKRRSTANNVEIVIPVP-------ADADSPKFKTTIGSCKYAPEQNAIIWTIKSFPGG 353
            .:|.:.....:|.|.||.:.:|:|       .:..||:.|..:.       :.|:.|.:....||
Human   321 YLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELA-------EGALRWDLPRVQGG 378

  Fly   354 KEYLMRAHF-----GLPSVESED-NTEGKP----PIQVRFEIPYFTTSGIQVRYLKIIEKSGYQA 408
            .:  :...|     |.|...|.. :|...|    |..:.||:|..|.||:|||:|::..:....|
Human   379 SQ--LSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNA 441

  Fly   409 LP--WVRYITQNGDYQLR 424
            .|  |||:::.:..|.:|
Human   442 NPHKWVRHLSHSDAYVIR 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	49/169 (29%)
		AP-1_Mu1A_Cterm	155..425	CDD:271166	81/293 (28%)
AP4M1	NP_001350600.1	AP4_Mu_N	3..148	CDD:341442	48/151 (32%)
		AP-4_Mu4_Cterm	182..460	CDD:271161	81/287 (28%)