Protein Alignment AP-1mu and AP4M1

DIOPT Version :9

• Sequence 1: NP_649906.1
• Gene: AP-1mu / 41150
• FlyBaseID: FBgn0024833
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001350600.1
• Gene: AP4M1 / 9179
• HGNCID: 574
• Length: 460
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 131/473 - (27%)
• Similarity: 228/473 - (48%)
• Gaps: 68/473 - (14%)

  Fly     4 SAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGL---ITPILQTAE--------TT 57
            |..|:|..||..||.:::|||:....|.:.|.     |:..||   .:|::....        ..
Human     3 SQFFILSSKGDPLIYKDFRGDSGGRDVAELFY-----RKLTGLPGDESPVVMVTSGGRRHHHGRH 62

  Fly    58 FAYIKTNNLYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLD 122
            |.:|:.:.||:|.||  ::||:...:...|.::|.:..:|...|.|.:|..|..::||||||:||
Human    63 FIHIRHSGLYLVVTT--SENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLD 125

  Fly   123 FGYPQTTDSKILQEYITQE------------------GHKLELQPRIPVAVTNAVSWRSEGIKYR 169
            :||.|||.:::|:.:|..|                  |.:.:.....|.:..:.....|...:.:
Human   126 YGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQ 190

  Fly   170 KNEVFLDVIESVNLLANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDK-VLFESTGRGKSKSV 233
            ||||||||:|.:::|..:||::|:.::.|.|:::.:|....|:|:||.:: .:.:|..||....:
Human   191 KNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGI 255

  Fly   234 ELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVK---PLIWIESVIERHAHSRVEY 295
            .:::|.||..|.|..||:.|.:...||.||..:|.|:|:..:.   |.....||.......|::.
Human   256 RVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQV 320

  Fly   296 MIKAKSQFKRRSTANNVEIVIPVP-------ADADSPKFKTTIGSCKYAPEQNAIIWTIKSFPGG 353
            .:|.:.....:|.|.||.:.:|:|       .:..||:.|..:.       :.|:.|.:....||
Human   321 YLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELA-------EGALRWDLPRVQGG 378

  Fly   354 KEYLMRAHF-----GLPSVESED-NTEGKP----PIQVRFEIPYFTTSGIQVRYLKIIEKSGYQA 408
            .:  :...|     |.|...|.. :|...|    |..:.||:|..|.||:|||:|::..:....|
Human   379 SQ--LSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNA 441

  Fly   409 LP--WVRYITQNGDYQLR 424
            .|  |||:::.:..|.:|
Human   442 NPHKWVRHLSHSDAYVIR 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	49/169 (29%)
		AP-1_Mu1A_Cterm	155..425	CDD:271166	81/293 (28%)
AP4M1	NP_001350600.1	Clat_adaptor_s	<64..137	CDD:261170	28/74 (38%)
		AP-4_Mu4_Cterm	182..460	CDD:271161	81/287 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810