DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1mu and AP1M1

DIOPT Version :9

Sequence 1:	NP_649906.1	Gene:	AP-1mu / 41150	FlyBaseID:	FBgn0024833	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001123996.1	Gene:	AP1M1 / 8907	HGNCID:	13667	Length:	435	Species:	Homo sapiens

Alignment Length:	438	Identity:	353/438 - (80%)
Similarity:	390/438 - (89%)	Gaps:	17/438 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGLITPILQTAETTFAYIKTNN 65
            ||:||::|||:||||||.|||||| :||:.::.|||:|||:||||:::|||......|.:||.||
Human     1 MSASAVYVLDLKGKVLICRNYRGD-VDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64

  Fly    66 LYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLDFGYPQTTD 130
            ||:|:|:  .||..::|||.||:|:.|||.|||||||||||||||||||||||||:|||||||||
Human    65 LYLVATS--KKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTD 127

  Fly   131 SKILQEYITQEGHKLEL-QPRIPVAVTNAVSWRSEGIKYRKNEVFLDVIESVNLL---------- 184
            ||||||||||||||||. .||.|..||||||||||||||||||||||||||||||
Human   128 SKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLGKYPGVGWLG 192

  Fly   185 --ANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLS 247
              .:||||||||||||:|||||:|||||||||||||||||::|||||||||||||||||||||||
Human   193 HTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLS 257

  Fly   248 RFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMIKAKSQFKRRSTANNV 312
            |||||||||||||||||||||||||||||||||||||||:|:|||:|||||||||||||||||||
Human   258 RFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNV 322

  Fly   313 EIVIPVPADADSPKFKTTIGSCKYAPEQNAIIWTIKSFPGGKEYLMRAHFGLPSVESEDNTEGKP 377
            ||.||||.||||||||||:||.|:.||.:.|:|:||||||||||||||||||||||:||. ||||
Human   323 EIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDK-EGKP 386

  Fly   378 PIQVRFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRT 425
            ||.|:|||||||||||||||||||||||||||||||||||||||||||
Human   387 PISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRT 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	99/140 (71%)
AP-1mu	NP_649906.1	AP-1_Mu1A_Cterm	155..425	CDD:271166	244/281 (87%)
AP1M1	NP_001123996.1	AP1_Mu_N	4..142	CDD:341439	99/140 (71%)
AP1M1	NP_001123996.1	AP-1_Mu1A_Cterm	153..434	CDD:271166	244/281 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154956
Domainoid	1	1.000	491	1.000	Domainoid score	I369
eggNOG	1	0.900	-	-		E1_KOG0937
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4017
Inparanoid	1	1.050	706	1.000	Inparanoid score	I660
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54006
OrthoDB	1	1.010	-	-		D246783at33208
OrthoFinder	1	1.000	-	-		FOG0001611
OrthoInspector	1	1.000	-	-		oto88645
orthoMCL	1	0.900	-	-		OOG6_101263
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R59
SonicParanoid	1	1.000	-	-		X1021
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800