DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1mu and ap1m3

DIOPT Version :9

Sequence 1:	NP_649906.1	Gene:	AP-1mu / 41150	FlyBaseID:	FBgn0024833	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001107913.1	Gene:	ap1m3 / 445244	ZFINID:	ZDB-GENE-040801-159	Length:	423	Species:	Danio rerio

Alignment Length:	427	Identity:	322/427 - (75%)
Similarity:	370/427 - (86%)	Gaps:	5/427 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGLITPILQTAETTFAYIKTNN 65
            |::||||:||:||||||.|||.| ||||.|||.|||::|:||||..::|::....|.|.:||.:|
Zfish     1 MAASAIFILDLKGKVLICRNYMG-NIDMNVIDNFMPIMMKREEEAELSPVVIHGSTHFLWIKHSN 64

  Fly    66 LYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLDFGYPQTTD 130
            ||:|:.|  .||.|.|||:.||:|:.:||.||||.|||||||||||.:|||:||::|||:|||||
Zfish    65 LYLVAMT--KKNTNAALVYSFLYKLVEVFTEYFKSLEEESIRDNFVTVYELMDEVMDFGFPQTTD 127

  Fly   131 SKILQEYITQEGHKLEL-QPRIPVAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLANANGNVLRS 194
            ||||.|||||:|||||: .||.|..||||||||||||||||||||:|||||||||.:|.|:||||
Zfish   128 SKILLEYITQQGHKLEVGAPRPPATVTNAVSWRSEGIKYRKNEVFMDVIESVNLLVSATGSVLRS 192

  Fly   195 EIVGAIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIP 259
            ||:|.||::|.||||||||||||||||||.|||.|:|||||||||||||||||||||||||||||
Zfish   193 EILGCIKLKVVLSGMPELRLGLNDKVLFEITGREKTKSVELEDVKFHQCVRLSRFENDRTISFIP 257

  Fly   260 PDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIVIPVPADADS 324
            ||||.|||||||||.||||||||||||:.:|||||..:||:||||.|||||||.|::|||:||||
Zfish   258 PDGESELMSYRLNTTVKPLIWIESVIEKFSHSRVEIKVKARSQFKSRSTANNVSILVPVPSDADS 322

  Fly   325 PKFKTTIGSCKYAPEQNAIIWTIKSFPGGKEYLMRAHFGLPSVESEDNTEGKPPIQVRFEIPYFT 389
            ||||||.|..|:.||::|:.|.|||||||||::|||||||||||| |..|||.||.|:|||||||
Zfish   323 PKFKTTTGQAKWVPEKSAVEWNIKSFPGGKEFMMRAHFGLPSVES-DELEGKRPITVKFEIPYFT 386

  Fly   390 TSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN 426
            .||||||||||||||||||||||||.||:||||||||
Zfish   387 VSGIQVRYLKIIEKSGYQALPWVRYTTQSGDYQLRTN 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	91/140 (65%)
AP-1mu	NP_649906.1	AP-1_Mu1A_Cterm	155..425	CDD:271166	221/269 (82%)
ap1m3	NP_001107913.1	Clat_adaptor_s	5..139	CDD:261170	88/136 (65%)
ap1m3	NP_001107913.1	AP_MHD_Cterm	153..422	CDD:299401	221/269 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3451
eggNOG	1	0.900	-	-		E1_KOG0937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4017
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54006
OrthoDB	1	1.010	-	-		D246783at33208
OrthoFinder	1	1.000	-	-		FOG0001611
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101263
Panther	1	1.100	-	-	O	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R59
SonicParanoid	1	1.000	-	-		X1021
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.820