DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1mu and Ap4m1

DIOPT Version :9

Sequence 1:	NP_649906.1	Gene:	AP-1mu / 41150	FlyBaseID:	FBgn0024833	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	XP_006249070.1	Gene:	Ap4m1 / 304344	RGDID:	1310233	Length:	457	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	128/468 - (27%)
Similarity:	227/468 - (48%)	Gaps:	61/468 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGL---ITPILQTAETT-FAYIKTN 64
            |..|:|..||..||.:::|||:....|.:.|.     |:..||   .:|::...:.. |.:|:.:
  Rat     3 SQFFILSSKGDPLIYKDFRGDSGGRDVAELFY-----RKLTGLPGGESPVVMYHDDRHFIHIRHS 62

  Fly    65 NLYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLDFGYPQTT 129
            .||:|:||  ::||:...:...|.::|.:..:|...|.|.:|..|..::||||||:||:||.|||
  Rat    63 GLYLVATT--SENVSPFSLLELLSRLATLLGDYCGSLNEGTISRNVALVYELLDEVLDYGYVQTT 125

  Fly   130 DSKILQEYITQE------------------GHKLELQPRIPVAVTNAVSWRSEGIKYRKNEVFLD 176
            .:.:|:.:|..|                  |.:.:.....|.:..:.....|...:.:|||||||
  Rat   126 STDMLRNFIQTEAAVSKPFSLFDLSSVGLFGAETQQNRVAPSSAASRPVLSSRSDQSQKNEVFLD 190

  Fly   177 VIESVNLLANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDK-VLFESTGRGKSKSVELEDVKF 240
            |:|.:::|..:||::|:.::.|.|:::.:|....|:.:||.:: .:.:|..||....:.:::|.|
  Rat   191 VVERLSVLIASNGSLLKVDVQGEIRLKSFLPSSSEICIGLTEEFCVGKSELRGYGPGIRVDEVSF 255

  Fly   241 HQCVRLSRFENDRTISFIPPDGE--FEL--MSYRLNTHVK---PLIWIESVIERHAHSRVEYMIK 298
            |..|.|..||:.|.:...||.||  |.|  |.|:|:..:.   |.....||.......|::..:|
  Rat   256 HSSVNLDEFESHRILHLQPPQGEVRFRLTVMRYQLSDDLPSPLPFRLFPSVQWDQGSGRLQVYLK 320

  Fly   299 AKSQFKRRSTANNVEIVIPVP-------ADADSPKFKTTIGSCKYAPEQNAIIWTIKSFPGGKEY 356
            .:.....:|.|.|:.:.:|:|       .:..||..|..:|       :.|:.|.:....||.:.
  Rat   321 LRCDLPPKSQALNIHLHLPLPRGVVSLSQELSSPDQKAELG-------EGALHWDLPRVQGGSQL 378

  Fly   357 LMRAHFGLPSVESEDNTEGKP--------PIQVRFEIPYFTTSGIQVRYLKIIEKSGYQALP--W 411
            .......:|.::...:....|        |..:.||:|..|.||:|||:|::...:...|.|  |
  Rat   379 SGLFQMDVPGLQGPPSRGPSPSAPPLGLGPASLSFELPRHTCSGLQVRFLRLSFSACGNANPHKW 443

  Fly   412 VRYITQNGDYQLR 424
            ||:::.:..|.:|
  Rat   444 VRHLSHSNAYVIR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	49/162 (30%)
AP-1mu	NP_649906.1	AP-1_Mu1A_Cterm	155..425	CDD:271166	78/295 (26%)
Ap4m1	XP_006249070.1	Clat_adaptor_s	1..130	CDD:261170	45/133 (34%)
Ap4m1	XP_006249070.1	AP-4_Mu4_Cterm	175..457	CDD:271161	78/289 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810