DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1mu and apm4

DIOPT Version :9

Sequence 1:	NP_649906.1	Gene:	AP-1mu / 41150	FlyBaseID:	FBgn0024833	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_592921.1	Gene:	apm4 / 2541527	PomBaseID:	SPAC31A2.09c	Length:	446	Species:	Schizosaccharomyces pombe

Alignment Length:	454	Identity:	161/454 - (35%)
Similarity:	246/454 - (54%)	Gaps:	44/454 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGLITPILQTAETTFAYIKTNNLYI 68
            |.:|:.::||..||.:.:|.| :..:|.:.|...::...:  ...||:....:|:.|.|..:||:
pombe     3 SGLFIFNLKGDTLICKTFRHD-LKKSVTEIFRVAILTNTD--YRHPIVSIGSSTYIYTKHEDLYV 64

  Fly    69 VSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLDFGYPQTTDSKI 133
            |:.|..|.||.|  |..||..:.|....||.:|.|.:::||...|:|||||::|:|..|||:...
pombe    65 VAITKGNPNVMI--VLEFLESLIQDLTHYFGKLNENTVKDNVSFIFELLDEMIDYGIIQTTEPDA 127

  Fly   134 LQEYIT-------------QEGHKLELQPRIPVAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLA 185
            |...::             :..|..:|.......:..:|.||..|||||||.:::|::|.:|||.
pombe   128 LARSVSITAVKKKGNALSLKRSHSSQLAHTTSSEIPGSVPWRRAGIKYRKNSIYIDIVERMNLLI 192

  Fly   186 NANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFE-STGRGKSKS-------------VELE 236
            ::.||||||::.|.:|||..||||||.:.|||||:.|: .....||||             |.||
pombe   193 SSTGNVLRSDVSGVVKMRAMLSGMPECQFGLNDKLDFKLKQSESKSKSNNSRNPSSVNGGFVILE 257

  Fly   237 DVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMIKAKS 301
            |.:|||||||..|||:..|:|||||||.||||||.:.::.....|..::|:.:..::.|.|..::
pombe   258 DCQFHQCVRLPEFENEHRITFIPPDGEVELMSYRSHENINIPFRIVPIVEQLSKQKIIYRISIRA 322

  Fly   302 QFKRRSTANNVEIVIPVPADADSPKFKTTIGSCKYAPEQNAIIWTIKSFPGGKEYLMRAHFGLPS 366
            .:..: .::::...||||.:......:...|...|.|.:|.|.|.|..|.|..|.:..|     .
pombe   323 DYPHK-LSSSLNFRIPVPTNVVKANPRVNRGKAGYEPSENIINWKIPRFLGETELIFYA-----E 381

  Fly   367 VESEDNTE----GKPPIQVRFEIPYFTTSGIQVRYLKIIEKSG--YQALPWVRYITQNGDYQLR 424
            ||..:.|.    .||||.:.|.|..||:||:.|:||::.|.|.  |:::.||||.|:.|..::|
pombe   382 VELSNTTNQQIWAKPPISLDFNILMFTSSGLHVQYLRVSEPSNSKYKSIKWVRYSTRAGTCEIR 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	46/153 (30%)
AP-1mu	NP_649906.1	AP-1_Mu1A_Cterm	155..425	CDD:271166	114/290 (39%)
apm4	NP_592921.1	Clat_adaptor_s	1..134	CDD:261170	45/135 (33%)
apm4	NP_592921.1	AP-2_Mu2_Cterm	175..445	CDD:271159	107/275 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910