DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1mu and Ap1m2

DIOPT Version :9

Sequence 1:	NP_649906.1	Gene:	AP-1mu / 41150	FlyBaseID:	FBgn0024833	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001103770.1	Gene:	Ap1m2 / 11768	MGIID:	1336974	Length:	425	Species:	Mus musculus

Alignment Length:	429	Identity:	323/429 - (75%)
Similarity:	378/429 - (88%)	Gaps:	7/429 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEGLITPILQTAETTFAYIKTNN 65
            ||:||:|:||||||.||||||:|| :.|..||.||||||:|||||::.|:|......|.:||.:|
Mouse     1 MSASAVFILDVKGKPLISRNYKGD-VPMTEIDHFMPLLMQREEEGVLAPLLSHGRVHFLWIKHSN 64

  Fly    66 LYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELLDFGYPQTTD 130
            ||:|:||  .||.|.:||:.||:|..:||.|||||||||||||||||:|||||||:|||:|||||
Mouse    65 LYLVATT--LKNANASLVYSFLYKTVEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTD 127

  Fly   131 SKILQEYITQEGHKLEL-QPRIPVAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLANANGNVLRS 194
            ||||||||||:|:|||. :.|:|..||||||||||||||:|||||:|||||||||.||||:||.|
Mouse   128 SKILQEYITQQGNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLS 192

  Fly   195 EIVGAIKMRVYLSGMPELRLGLNDKVLFESTG--RGKSKSVELEDVKFHQCVRLSRFENDRTISF 257
            ||||.||::|:|||||||||||||:||||.||  ..|:|||||||||||||||||||:|||||||
Mouse   193 EIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKFHQCVRLSRFDNDRTISF 257

  Fly   258 IPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIVIPVPADA 322
            |||||:||||||||:|.||||||||||||:.:|||||.|:|||.|||::|.||.|||.:|||:||
Mouse   258 IPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDA 322

  Fly   323 DSPKFKTTIGSCKYAPEQNAIIWTIKSFPGGKEYLMRAHFGLPSVESEDNTEGKPPIQVRFEIPY 387
            |||:|||::||.||.||:|.:||:||||||||||||||||||||||:|: .||:|||.|:|||||
Mouse   323 DSPRFKTSVGSAKYVPEKNVVIWSIKSFPGGKEYLMRAHFGLPSVETEE-VEGRPPIGVKFEIPY 386

  Fly   388 FTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN 426
            ||.|||||||:|||||||||||||||||||:|||||||:
Mouse   387 FTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDYQLRTS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	95/140 (68%)
AP-1mu	NP_649906.1	AP-1_Mu1A_Cterm	155..425	CDD:271166	219/271 (81%)
Ap1m2	NP_001103770.1	AP1_Mu_N	4..142	CDD:341439	95/140 (68%)
Ap1m2	NP_001103770.1	AP_MHD_Cterm	154..423	CDD:416027	217/269 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3425
eggNOG	1	0.900	-	-		E1_KOG0937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54006
OrthoDB	1	1.010	-	-		D246783at33208
OrthoFinder	1	1.000	-	-		FOG0001611
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101263
Panther	1	1.100	-	-	O	PTHR10529
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1021
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790