Protein Alignment AP-1mu and AP2M1

DIOPT Version :10

• Sequence 1: NP_649906.1
• Gene: AP-1mu / 41150
• FlyBaseID: FBgn0024833
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001298127.1
• Gene: AP2M1 / 1173
• HGNCID: 564
• Length: 460
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 181/461 - (39%)
• Similarity: 272/461 - (59%)
• Gaps: 48/461 - (10%)

  Fly     6 IFVLDVKGKVLISRNYRGD-----NIDMAV-------------------IDKFMPLLMEREEEGL 46
            :|:.:.||:|||||.||.|     ..|.||                   :|.|...::...:: :
Human     5 LFIYNHKGEVLISRVYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVNVIHARQQ-V 68

  Fly    47 ITPILQTAETTFAYIKTNNLYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFV 111
            .:|:...|.|:|.::|.:|:::.:.|  .:|||.|:||.||:|:..|...||.::.||:|::|||
Human    69 RSPVTNIARTSFFHVKRSNIWLAAVT--KQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFV 131

  Fly   112 IIYELLDELLDFGYPQTTDSKILQEYITQEGHK-----LELQPRIPVAVTNAVSWRSEGIKYRKN 171
            :|||||||:|||||||.:::..|:.:|||:|.|     .|.|.:|...||..:.||.||||||:|
Human   132 LIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRN 196

  Fly   172 EVFLDVIESVNLLANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFESTGRGKS------ 230
            |:||||:||||||.:..|.||.:.:.|.:.|:.|||||||.:.|:|||::.|..|:|.:
Human   197 ELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKS 261

  Fly   231 --KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRV 293
              :|:.::|..||||||||:|:::|:|||||||||||||.||....:.....:..::.....:::
Human   262 GKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKL 326

  Fly   294 EYMIKAKSQFKRRSTANNVEIVIPVPADADSPKFKTTIGSCKYAPEQNAIIWTIKSFPGGKEYLM 358
            |..:..||.||....|..:|:.||.|.:....:.....|..||...:|||:|.||...|.||..:
Human   327 EVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQI 391

  Fly   359 RAHFGLPSVESEDNTE-GKPPIQVRFEIPYFTTSGIQVRYLKIIEK----SGYQALPWVRYITQN 418
            .|...|  :.:.|..: .:|||.:.||:| |..||::|||||:.|.    |.:..:.|||||.::
Human   392 SAEIEL--LPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRS 453

  Fly   419 GDYQLR 424
            |.|:.|
Human   454 GIYETR 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1mu	NP_649906.1	AP1_Mu_N	4..145	CDD:341439	61/167 (37%)
		AP-1_Mu1A_Cterm	155..425	CDD:271166	117/283 (41%)
AP2M1	NP_001298127.1	AP2_Mu_N	1..165	CDD:341440	60/162 (37%)
		AP-2_Mu2_Cterm	193..459	CDD:271159	108/268 (40%)