DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAGEB4 and MAGE

DIOPT Version :9

Sequence 1:	NP_002358.1	Gene:	MAGEB4 / 4115	HGNCID:	6811	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_649702.2	Gene:	MAGE / 40860	FlyBaseID:	FBgn0037481	Length:	232	Species:	Drosophila melanogaster

Alignment Length:	221	Identity:	58/221 - (26%)
Similarity:	107/221 - (48%)	Gaps:	16/221 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    92 ASSSQASTSTE-------RSLKDSLTRKTKMLVQFLLYKYKMKEPTTKAEMLKIISKK--YKEHF 147
            ||:|:|:.|..       :...|.:..|.:.::.::|.....|.|....:::.:...|  .|:..
  Fly     2 ASTSRAARSQNAIPSQEAQQPVDVVDAKVRAILNYILDHTAQKIPIKDKDLIAVAGDKSELKKRL 66

Human   148 PEIFRKVSQRTELVFGLALKEVNPTTHSYILVSMLGPNDGNQSSAWTLPRNGLLMPLLSVIFLNG 212
            |.:...:::    .||:.|..::.||.::|..:.......::.:....|:..||..:|..|||.|
  Fly    67 PLVTNLLAE----TFGIILTPLDATTKTFICTAEEPVASIHELTPAQRPQFTLLYIILMYIFLRG 127

Human   213 NCAREEEIWEFLNMLGIYDGKRHLIFG-EPRKLITQDLVQEKYL--EYQQVPNSDPPRYQFLWGP 274
            |...:.:::..|.||.||..:.|..|| ..||.|.:..|:::||  |..|:...|..:..|||||
  Fly   128 NRIEDSKLYVMLEMLNIYPDEEHGYFGPNLRKQIEETFVKQQYLKRERSQLSAYDDSKTFFLWGP 192

Human   275 RAHAETSKMKVLEFLAKVNDTTPNNF 300
            ||.||.:..::::|.:|:.:..|..|
  Fly   193 RAKAEFTFEQMVQFASKLLNQHPKVF 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAGEB4	NP_002358.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		5/21 (24%)
		MAGE_N	5..91	CDD:289225
		MAGE	129..283	CDD:279759	45/158 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..346
MAGE	NP_649702.2	MAGE	36..201	CDD:279759	47/168 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151950
Domainoid	1	1.000	63	1.000	Domainoid score	I10231
eggNOG	1	0.900	-	-		E1_KOG4562
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5087
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1195799at2759
OrthoFinder	1	1.000	-	-		FOG0000171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.860