Protein Alignment BckdhA and BCKDHA

DIOPT Version :10

• Sequence 1: NP_649905.1
• Gene: BckdhA / 41149
• FlyBaseID: FBgn0037709
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_000700.1
• Gene: BCKDHA / 593
• HGNCID: 986
• Length: 445
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 243/407 - (59%)
• Similarity: 310/407 - (76%)
• Gaps: 4/407 - (0%)

  Fly    33 RDFSSKPSEDYANFPGAKAPFVSKLNLIQPEDYAPIPIYRVMDQDGYIADETQDPQLGREVVEKM 97
            :.|||  .:|...||||.|.|:.||..|||...:.||||||||:.|.|.:.::||.|.:|.|.|:
Human    43 QQFSS--LDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKL 105

  Fly    98 FRDMVLLNTMDKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFR 162
            ::.|.||||||:|||||||||||||||||:|||.:|:||||||:..||::|||||||||::|.:.
Human   106 YKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYP 170

  Fly   163 IDQFIDQCYGNTDDLGRGKQMPVHYGSRELNFVTISSPLSTQMPQAVGAAYAMKLRPNNDACVVC 227
            ::.|:.|||||..|||:|:|||||||.:|.:||||||||:||:|||||||||.| |.|.:..|:|
Human   171 LELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAK-RANANRVVIC 234

  Fly   228 YFGEGAASEGDAHAAFNFAATLGCPAILFCRNNGFAISTPSHEQYKGDGIAGRGPMGYGITTIRV 292
            ||||||||||||||.|||||||.||.|.||||||:|||||:.|||:|||||.||| ||||.:|||
Human   235 YFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGP-GYGIMSIRV 298

  Fly   293 DGTDVFAVYNAMKAAREYVLKENKPVVFEALAYRVGHHSTSDDSTAYRPAEEIEIWNSVEHPISK 357
            ||.||||||||.|.||...:.||:|.:.||:.||:|||||||||:|||..:|:..|:..:||||:
Human   299 DGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISR 363

  Fly   358 LKRYMVHKGWFDETVENEYVKDIRKKVLKQIAVSEKKLKPNWREMFEGVYAEMPDHLIEQRSELE 422
            |:.|::.:||:||..|..:.|..|:||::....:|:|.|||...:|..||.|||..|.:|:..|.
Human   364 LRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLA 428

  Fly   423 KHIEAHKEHYPLKDFEK 439
            :|::.:.|||||..|:|
Human   429 RHLQTYGEHYPLDHFDK 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BckdhA	NP_649905.1	TPP_E1_PDC_ADC_BCADC	97..389	CDD:238958	190/291 (65%)
BCKDHA	NP_000700.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..52		4/10 (40%)
		AcoA	80..429	CDD:440689	216/350 (62%)