Protein Alignment RnpS1 and PABPN1

DIOPT Version :9

• Sequence 1: NP_649903.1
• Gene: RnpS1 / 41147
• FlyBaseID: FBgn0037707
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 64/301 - (21%)
• Similarity: 111/301 - (36%)
• Gaps: 59/301 - (19%)

  Fly    79 SSSSSSSSSSDSDRSEKNRRR-----GGGAAGKDKDKDKPSARSRSRSRTRSPRRVSKSPRPGSK 138
            :::::::.::....|...|||     .||.||:..........:...|....|..:...|.|..:
Human     5 AAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPE 69

  Fly   139 ARKEPERDR-----------DRRSRSRDRARRAG-----SNDRAAADS--NNVK---RERSRSAS 182
            ..:||.|.|           .....|::.....|     ..|.|..|.  ..:|   ||....|.
Human    70 PEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAE 134

  Fly   183 RSRSPRRRGRGSVERTPPPKR--------RERSRSRTRSPSPKQVRIHVGRLTRNVTKDHVFEIF 239
            :.:..:......:..:|||..        .|:..:..||       |:||.:....|.:.:...|
Human   135 KLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARS-------IYVGNVDYGATAEELEAHF 192

  Fly   240 SSFGDVKNVEFPVDRF--HPNFGRGVAFVEYATPEDCESAMKHMDGGQIDGQEITVSPVVLVKQ- 301
            ...|.|..|....|:|  ||   :|.|::|::..|...:::. :|.....|::|.|.|    |:
Human   193 HGCGSVNRVTILCDKFSGHP---KGFAYIEFSDKESVRTSLA-LDESLFRGRQIKVIP----KRT 249

  Fly   302 -RPPMR---RPSPPMR-RPQNNRWRSPPQ--FNRFNNRGGG 335
             ||.:.   |..|..| |.:...:.|...  ::.||:|..|
Human   250 NRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRG 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RnpS1	NP_649903.1	RRM	<196..>301	CDD:223796	27/114 (24%)
		RRM_RNPS1	221..294	CDD:240811	19/74 (26%)
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		20/109 (18%)
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145		25/139 (18%)
		GCG-encoded polyalanine repeat	2..7		0/1 (0%)
		RRM	113..>289	CDD:223796	44/190 (23%)
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147		4/27 (15%)
		Necessary for homooligomerization	155..306		36/151 (24%)
		RRM_II_PABPN1	173..248	CDD:409966	22/89 (25%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306		2/5 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4209
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900