DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RnpS1 and Sart3

DIOPT Version :9

Sequence 1:	NP_649903.1	Gene:	RnpS1 / 41147	FlyBaseID:	FBgn0037707	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001343550.1	Gene:	Sart3 / 53890	MGIID:	1858230	Length:	980	Species:	Mus musculus

Alignment Length:	215	Identity:	44/215 - (20%)
Similarity:	94/215 - (43%)	Gaps:	24/215 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 AAGKDKDKDKPSARSRSRSRTRSPRRVSKSPRPGSKARKEPERDRD--RRSRSRDRARRAGSNDR 165
            ||...::::|...|.:.|:..::.:: .|..|...|.|::.:.:.:  .....:...||...|..
Mouse   607 AALVQQEEEKAEQRKKVRAEKKALKK-KKKTRGADKRREDEDEENEWGEEEEEQPSKRRRTENSL 670

  Fly   166 AAADSNNVKRERSRSASRSRSPRRRGRGSVERTPPPKRRERSRSRTR-------SPSPKQVRIHV 223
            |:.:::.:|.|...|....         :::..||.|::|::.|..|       ..|...|.:.|
Mouse   671 ASGEASAMKEETELSGKCL---------TIDVGPPSKQKEKAASLKRDMPKVAHDSSKDSVTVFV 726

  Fly   224 GRLTRNVTKDHV--FEIFSSFGDVKNVEFPVDRFHPNFGRGVAFVEYATPEDCESAMKHMDGGQI 286
            ..|..::.:..|  ..:|...|:|..:. |:.....:| ||..:||:...:..:.|:: :|...:
Mouse   727 SNLPYSIEEPEVKLRPLFEVCGEVVQIR-PIFSNRGDF-RGYCYVEFGEEKSAQQALE-LDRKIV 788

  Fly   287 DGQEITVSPVVLVKQRPPMR 306
            :|:.:.|||.|...:.|..:
Mouse   789 EGRPMFVSPCVDKSKNPDFK 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RnpS1	NP_649903.1	RRM	<196..>301	CDD:223796	27/113 (24%)
RnpS1	NP_649903.1	RRM_RNPS1	221..294	CDD:240811	15/74 (20%)
Sart3	NP_001343550.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		Suf	101..>479	CDD:331814
		HAT 5. /evidence=ECO:0000255	343..375
		HAT 6. /evidence=ECO:0000255	378..410
		HAT 7. /evidence=ECO:0000255	413..449
		HAT 8. /evidence=ECO:0000255	459..492
		Required for interaction with USP4. /evidence=ECO:0000250\|UniProtKB:Q15020	506..539
		Necessary and sufficient for U6 snRNA binding. /evidence=ECO:0000250\|UniProtKB:Q15020	556..970		44/215 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..714		20/114 (18%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q15020	619..688		13/69 (19%)
		RRM1_SART3	723..796	CDD:240837	15/75 (20%)
		RRM2_SART3	817..897	CDD:240838
		LSM_int_assoc	895..953	CDD:318746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15481
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100