Protein Alignment RnpS1 and Rnps1

DIOPT Version :10

• Sequence 1: NP_649903.1
• Gene: RnpS1 / 41147
• FlyBaseID: FBgn0037707
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_001011890.1
• Gene: Rnps1 / 287113
• RGDID: 1307522
• Length: 305
• Species: Rattus norvegicus
• Alignment Length: 379
• Identity: 156/379 - (41%)
• Similarity: 194/379 - (51%)
• Gaps: 103/379 - (27%)

  Fly     3 RAQSLAGEGEKEKDNKEKVAKE--KDGKATSGSSRRDRER---KRRGSASSSSDSRSSTSDSSSS 62
            ::.:.|....|.||..::.:|:  ||...|..||.:||.|   ::|.||||.|   |||...|||
  Rat    20 KSSTRAPSPTKRKDRSDEKSKDRSKDKGTTKESSEKDRGRDKTRKRRSASSGS---SSTRSRSSS 81

  Fly    63 RSSSGSSRSSSSSSSDSSSSSSSSSSDSDRSEKNRRRGGGAAGKDKDKDKPSARSRSRSRTRSPR 127
            .||||||.|:.|||..||||:||.|..|                            |.||:.|..
  Rat    82 TSSSGSSTSTGSSSGSSSSSASSRSGSS----------------------------STSRSSSSS 118

  Fly   128 RVSKSPRPGSKARKEPERDRDRRSRSRDRARRAGSNDRAAADSNNVKRERSRSASRSRSPRRRGR 192
            ..|.||.|                     :||...|           |.||||.|:
  Rat   119 SSSGSPSP---------------------SRRRHDN-----------RRRSRSKSK--------- 142

  Fly   193 GSVERTPPPKRRERSRSRTRSPSPKQVRIHVGRLTRNVTKDHVFEIFSSFGDVKNVEFPVDRFHP 257
                   ||||.|:.|.| ||||||..::|:|||||||||||:.||||::|.:|.::.||:|.||
  Rat   143 -------PPKRDEKERKR-RSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHP 199

  Fly   258 NFGRGVAFVEYATPEDCESAMKHMDGGQIDGQEITVSPVVLVKQRPPMRRPSPPMRR-PQNNRW- 320
            :..:|.|:||:..|::.|.|:||||||||||||||.:.|:....|||.||.|||.|. |....|
  Rat   200 HLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWR 264

  Fly   321 RSPPQFNRFNNRGGGGGGGGGRRQSPMRNRRSP-RRRSRSPIRRRRRSNSSDSS 373
            ||||:..|             |.:||  .|||| |||||||.|||.||.||.:|
  Rat   265 RSPPRMRR-------------RSRSP--RRRSPVRRRSRSPGRRRHRSRSSSNS 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RnpS1	NP_649903.1	RRM_RNPS1	221..294	CDD:409800	44/72 (61%)
Rnps1	NP_001011890.1	Necessary for interaction with the cleaved p110 isoform of CDC2L1. /evidence=ECO:0000250	1..220		102/279 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..170		77/229 (34%)
		Necessary for interaction with SRP54, nuclear localization and exon-skipping. /evidence=ECO:0000250	1..161		73/220 (33%)
		Necessary for interactions with UPF2 and UPF3B and UPF2-dependent NMD. /evidence=ECO:0000250	69..121		31/82 (38%)
		Necessary for interaction with PNN and exon-skipping. /evidence=ECO:0000250	156..242		49/85 (58%)
		Interaction with SAP18 and ACIN1. /evidence=ECO:0000250	159..244		46/84 (55%)
		RRM_RNPS1	163..236	CDD:409800	44/72 (61%)
		Necessary for interaction with TRA2B, nuclear localization and exon-skipping. /evidence=ECO:0000250	238..305		39/81 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..305		38/79 (48%)