DRSC/TRiP Functional Genomics Resources

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Protein Alignment RnpS1 and Rnps1

DIOPT Version :9

Sequence 1:NP_649903.1 Gene:RnpS1 / 41147 FlyBaseID:FBgn0037707 Length:374 Species:Drosophila melanogaster
Sequence 2:NP_001073596.1 Gene:Rnps1 / 19826 MGIID:97960 Length:305 Species:Mus musculus


Alignment Length:379 Identity:157/379 - (41%)
Similarity:195/379 - (51%) Gaps:103/379 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RAQSLAGEGEKEKDNKEKVAKE--KDGKATSGSSRRDRER---KRRGSASSSSDSRSSTSDSSSS 62
            ::.:.|....|.||..::.:|:  ||..||..||.:||.|   ::|.||||.|   |||...|||
Mouse    20 KSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGS---SSTRSRSSS 81

  Fly    63 RSSSGSSRSSSSSSSDSSSSSSSSSSDSDRSEKNRRRGGGAAGKDKDKDKPSARSRSRSRTRSPR 127
            .||||||.|:.|||..||||:||.|..|                            |.||:.|..
Mouse    82 TSSSGSSTSTGSSSGSSSSSASSRSGSS----------------------------STSRSSSSS 118

  Fly   128 RVSKSPRPGSKARKEPERDRDRRSRSRDRARRAGSNDRAAADSNNVKRERSRSASRSRSPRRRGR 192
            ..|.||.|                     :||...|           |.||||.|:         
Mouse   119 SSSGSPSP---------------------SRRRHDN-----------RRRSRSKSK--------- 142

  Fly   193 GSVERTPPPKRRERSRSRTRSPSPKQVRIHVGRLTRNVTKDHVFEIFSSFGDVKNVEFPVDRFHP 257
                   ||||.|:.|.| ||||||..::|:|||||||||||:.||||::|.:|.::.||:|.||
Mouse   143 -------PPKRDEKERKR-RSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHP 199

  Fly   258 NFGRGVAFVEYATPEDCESAMKHMDGGQIDGQEITVSPVVLVKQRPPMRRPSPPMRR-PQNNRW- 320
            :..:|.|:||:..|::.|.|:||||||||||||||.:.|:....|||.||.|||.|. |....| 
Mouse   200 HLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWR 264

  Fly   321 RSPPQFNRFNNRGGGGGGGGGRRQSPMRNRRSP-RRRSRSPIRRRRRSNSSDSS 373
            ||||:..|             |.:||  .|||| |||||||.|||.||.||.:|
Mouse   265 RSPPRMRR-------------RSRSP--RRRSPVRRRSRSPGRRRHRSRSSSNS 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RnpS1NP_649903.1 RRM <196..>301 CDD:223796 58/104 (56%)
RRM_RNPS1 221..294 CDD:240811 44/72 (61%)
Rnps1NP_001073596.1 Necessary for interaction with the cleaved p110 isoform of CDC2L1. /evidence=ECO:0000250 1..220 103/279 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..170 78/229 (34%)
Necessary for interaction with SRP54, nuclear localization and exon-skipping. /evidence=ECO:0000250 1..161 74/220 (34%)
Necessary for interactions with UPF2 and UPF3B and UPF2-dependent NMD. /evidence=ECO:0000250 69..121 31/82 (38%)
Necessary for interaction with PNN and exon-skipping. /evidence=ECO:0000250 156..242 49/85 (58%)
Interaction with SAP18 and ACIN1. /evidence=ECO:0000250 159..244 46/84 (55%)
RRM_RNPS1 163..236 CDD:409800 44/72 (61%)
Necessary for interaction with TRA2B, nuclear localization and exon-skipping. /evidence=ECO:0000250 238..305 39/81 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..305 38/79 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6780
eggNOG 1 0.900 - - E1_KOG4209
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 213 1.000 Inparanoid score I3627
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53121
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003226
OrthoInspector 1 1.000 - - oto93009
orthoMCL 1 0.900 - - OOG6_103512
Panther 1 1.100 - - LDO PTHR15481
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1169
SonicParanoid 1 1.000 - - X3729
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.950

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