DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mura and pja2

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_009300150.1	Gene:	pja2 / 565118	ZFINID:	ZDB-GENE-060526-337	Length:	661	Species:	Danio rerio

Alignment Length:	722	Identity:	131/722 - (18%)
Similarity:	220/722 - (30%)	Gaps:	236/722 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 GHNGRRYMSDNLNNPSSSMNGLINSGHHQRNYNDRNL---NNHFGNSEQNG----GPDHRDRAEG 564
            |||.|.  |.....|.:.:|      |.:|..||:.:   ..|....|::.    ..:|:..::.
Zfish    98 GHNRRH--SSLRRVPKAPLN------HFKRPKNDQVVPYDRKHCSGREKSKVWPIDENHKTNSKA 154

  Fly   565 SSY-NFMRNGGGSGGGGYGRNGSHYQHMAYGNNNGASTSTGGPGLMGELPSGSGLSGSSLSLNN- 627
            .|| |.......|.|.......|...|.|....:|.....|....:.:       |.|||...|
Zfish   155 LSYINIDAYEPDSSGAEEEDLSSDPSHAACRRLDGICELGGNVDSLDD-------SRSSLFRKNR 212

  Fly   628 --------GPGGLNSDSPSRKRR-RISGRPPNGPQPQHRCPMAHMQQGSPPLRRPRLRDVATSTQ 683
                    ....|..|:|..:|. :.:|:           |...::.|:|..    ..|.|::
Zfish   213 MKQMASSKDSTDLFDDTPDCQRTVKTNGK-----------PSFFLEDGAPKC----YGDTASA-- 260

  Fly   684 QQQQQYGHQVHHPQQQQQQPPSNYHPMHHHQPQPHYVPQQQVPPPHVQRSPWDLGSSGGSSGGAT 748
                     |.|...:|..|...:......:|:    .::|....|::|.........|...|:.
Zfish   261 ---------VSHKNTEQNNPGETFESEMVVRPK----IRKQTSETHLERRKRSEKEETGHLSGSA 312

  Fly   749 SSSSVGPILQQVQAPPQPPSHQQAVGY-PQAPPQ-------PASLMVDLN---LNQVPVNLQLRP 802
            ..:..|      .|||         |: .|..|:       ||..:.|||   ......|.::..
Zfish   313 IRNKCG------SAPP---------GFLAQTCPENKFLFNFPAMALSDLNSEDRKSEDENAKVED 362

  Fly   803 SEPFWASFCTYPIPAQARLAPCHLHGVYTQPFPAAPPPGLAAPPLQQQHQPLIQAQQMISQATLT 867
            .:..|...                     :.|.....|.:.|   .:......:.:...|..:.:
Zfish   363 EDDIWEDL---------------------ENFGEKCEPSMKA---DESSSEFSEGEWSASWTSDS 403

  Fly   868 AQQQQRDVVAIATANLGPIEAPGAHGHPHAHPHAHPHAHQLPPGIHITPLSGAAAAAATHHLHST 932
            ...::|     .|:.                     .:.:..|||...|.|.:::......|:..
Zfish   404 GLDKER-----CTSE---------------------ESWETLPGIDEPPASRSSSLEEVPSLNLA 442

  Fly   933 AAAAAAVAAGAQITTAQQILFSSDRRTFPPHRRIPRFWTANHGHRHVLPPQSLAAHQAPVQIQAT 997
            ......:..|    ....::::.|                          ...::.:.|   ...
Zfish   443 LEEQTPLEEG----EIPWLMYNED--------------------------SGSSSDEDP---DGV 474

  Fly   998 SGIINPGFLLNFLAMFPLSPYN--QHDLSSGDTNETE--------------------NYEALL-- 1038
            |..::||       :|.|...|  :.|.|..:..:||                    ::..||
Zfish   475 SQFVHPG-------LFILDGNNNLEDDSSMSEDLDTEWRFLDEFGDGFGMAQAISYVDHSQLLTY 532

  Fly  1039 -SLAERLGEAKPRGL-----------------TRNEIDQLPSYKFNPEVHNGDQSS-CVVCMCDF 1084
             :|.|||.:|....|                 |...||.||....:.|  |.:|.. |.:|.|::
Zfish   533 MALEERLAQAMEAALAHLESLAIDVEQAHPPATEQIIDCLPQITMHAE--NIEQEQCCAICCCEY 595

  Fly  1085 ELRQLLRVLPCSHEFHAKCVDKWLRSNRTCPICR-----GNASDYFDGVDQQQQSQATAGAAAAL 1144
            ...::..:|||.|.||..||..|||.:.|||:||     ...:|......:|:.|.:|..|
Zfish   596 VKDEIATLLPCRHMFHKLCVTLWLRKSGTCPVCRHVLTPAVTTDPASLSSEQETSPSTHSA---- 656

  Fly  1145 SGTSGGS 1151
               |||:
Zfish   657 ---SGGA 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	17/42 (40%)
pja2	XP_009300150.1	zf-RING_2	588..629	CDD:290367	17/40 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910