Protein Alignment mura and RNF130

DIOPT Version :10

• Sequence 1: NP_731367.2
• Gene: mura / 41145
• FlyBaseID: FBgn0037705
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_060904.2
• Gene: RNF130 / 55819
• HGNCID: 18280
• Length: 419
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 68/331 - (20%)
• Similarity: 107/331 - (32%)
• Gaps: 129/331 - (38%)

  Fly   821 LAPCHLHGVYTQPFPAAPPPGLAAPPLQQQHQPLIQA-----QQMISQATLTAQQQQRDVVAIAT 880
            |||..|||| .......|......||..:|...|:|.     ::.||:|..      .:.||:..
Human    75 LAPLPLHGV-ADHLGCDPQTRFFVPPNIKQWIALLQRGNCTFKEKISRAAF------HNAVAVVI 132

  Fly   881 ANLGPIEAPGAHGHPHAHPHAHPHAHQLPPGIHITPLSGAAAAAATHHLHSTAAAAAAVAAGAQI 945
            .|....|.|....||......         .:.||.|.|....:   :|....:....:|.|.:
Human   133 YNNKSKEEPVTMTHPGTGDII---------AVMITELRGKDILS---YLEKNISVQMTIAVGTR- 184

  Fly   946 TTAQQILFSSDRRTFPPHRRIPRFWTANHGHRHVLPPQSLAAHQAPVQIQATSGIINPGFL---- 1006
                                              :||::.:.                |.|
Human   185 ----------------------------------MPPKNFSR----------------GSLVFVS 199

  Fly  1007 LNFLAMFPLSP------------YNQHDLSSGDTNETENYEALLSLAERLGEAKPRGL----TRN 1055
            ::|:.:..:|.            |.    ::.|.|:           .|||:|..:.:    ||.
Human   200 ISFIVLMIISSAWLIFYFIQKIRYT----NARDRNQ-----------RRLGDAAKKAISKLTTRT 249

  Fly  1056 EIDQLPSYKFNPEVHNGDQSS------CVVCMCDFELRQLLRVLPCSHEFHAKCVDKWLRSNRTC 1114
                         |..||:.:      |.||:..::...::|:|||.|.||..|||.||..:.||
Human   250 -------------VKKGDKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTC 301

  Fly  1115 PICRGN 1120
            |:|:.|
Human   302 PMCKLN 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	RING-H2_RNF38-like	1073..1118	CDD:438135	19/50 (38%)
RNF130	NP_060904.2	PA_GRAIL_like	40..179	CDD:239037	28/122 (23%)
		HRD1	<197..>306	CDD:227568	33/136 (24%)
		RING-H2_RNF130	262..310	CDD:319717	20/46 (43%)