DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mura and RLIM

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_057204.2	Gene:	RLIM / 51132	HGNCID:	13429	Length:	624	Species:	Homo sapiens

Alignment Length:	724	Identity:	145/724 - (20%)
Similarity:	245/724 - (33%)	Gaps:	228/724 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 QGQGPGNSPNLGHNHQRGYNNGNNNRGIGNG--IVNGNTNGPPDYMNYRRGVCPAQSRDYSGNGN 500
            :|..|.||     :..||   |:::..:.||  |:        |::|             |....
Human    73 EGPPPQNS-----DENRG---GDSSDDVSNGDSII--------DWLN-------------SVRQT 108

  Fly   501 GNNNGHGHNGRR-YMSDNLNNPSSSMNGLINSGHHQRNYN-DRNLNNHFGNSEQNGGPDHRDRAE 563
            ||....|..|.: :.:.:..||        |||..:.:.. :.|.||...|||....|..| |:.
Human   109 GNTTRSGQRGNQSWRAVSRTNP--------NSGDFRFSLEINVNRNNGSQNSENENEPSAR-RSS 164

  Fly   564 GSSYNFMRNGGGSGGGGYGRNGSHYQHMAYGNNNGASTSTGGPGLMGELPSGSGLSGSSLSLNNG 628
            |.:.               .|.|..|   ..|....|||                :..|.|..|.
Human   165 GENV---------------ENNSQRQ---VENPRSESTS----------------ARPSRSERNS 195

  Fly   629 PGGLNSDSPSRKRRRISGRPPNGPQPQHRCPMAHMQQGSPPLRR----PRLRDVATSTQQQQQQY 689
            ...|....|:|.:||...|     .|.||...|..::...||..    ||....:.|:|
Human   196 TEALTEVPPTRGQRRARSR-----SPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQ------ 249

  Fly   690 GHQVHHPQQQQQQPPSNYHPMHHHQPQPHYVPQQQVPPPH-VQRSPWDLGSSGGSSGGATSSSSV 753
              ...||...:.:..|        :.:.|...:||:..|. :.|..:....:..:|.||.||.:.
Human   250 --TFEHPLVNETEGSS--------RTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTA 304

  Fly   754 GPILQQVQAPPQPPSHQQAVGYPQAPPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTY----P 814
                          :..::.|..|.||   ::::||.:.:|      ||.|        |    .
Human   305 --------------ASGESTGSGQRPP---TIVLDLQVRRV------RPGE--------YRQRDS 338

  Fly   815 IPAQAR---LAPCHL------HGVYTQPFPAAPPPGLAA------PPLQQ------QHQPLIQAQ 858
            |.::.|   ..|.:.      .|.:.:.|..:...|:..      .|:::      .....:..|
Human   339 IASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQ 403

  Fly   859 QMISQAT---------LTAQQQQRDVVAIATANLGPIEAPGAHGHPHAHPHAHPHAHQLPPGIHI 914
            .|:.|..         :.:........:::..|:...|:....|.              ..|...
Human   404 TMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGG--------------SGGGSS 454

  Fly   915 TPLSGAAAAAATHHLHSTAAAAAAVAAGAQITTAQQILFSSDRRTFPPHRRIPRFWTANHGHRHV 979
            :..|.:::::::....|:::::.:.::|.:.:.....||.........        :.:.|.|..
Human   455 SGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSS--------SGSSGARRE 511

  Fly   980 LPPQSLAAHQAPVQIQATSGIINPGFLLNFLAMFPLSPYNQHDLSSGDTNETENYEALLSLAERL 1044
                  ..|:|||....:..       |.||::......|:.|
Human   512 ------GRHRAPVTFDESGS-------LPFLSLAQFFLLNEDD---------------------- 541

  Fly  1045 GEAKPRGLTRNEIDQLPSYKFNPEVHNGDQSSCVVCMCDFELRQLLRVLPCSHEFHAKCVDKWLR 1109
             :.:|||||:.:||.|....|.   .|....:|.||:.::.....||.||||||:|..|:|:||.
Human   542 -DDQPRGLTKEQIDNLAMRSFG---ENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLS 602

  Fly  1110 SNRTCPICR 1118
            .|.||||||
Human   603 ENSTCPICR 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	21/41 (51%)
RLIM	NP_057204.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..251		58/262 (22%)
		PHA03307	159..>348	CDD:223039	55/275 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..276		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..363		20/102 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..522		15/125 (12%)
		RING_Ubox	568..612	CDD:388418	23/44 (52%)
		PDZ-binding. /evidence=ECO:0000255	621..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4530
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.930