DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mura and RNF165

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_689683.2	Gene:	RNF165 / 494470	HGNCID:	31696	Length:	346	Species:	Homo sapiens

Alignment Length:	400	Identity:	101/400 - (25%)
Similarity:	150/400 - (37%)	Gaps:	112/400 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   755 PILQQVQ---APPQPPSHQQAVG---YPQAPPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTY 813
            |:...|:   ||.|...|..|..   :...||||.               ||.|..|.     .:
Human    12 PVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQPQ---------------QLAPDFPL-----AH 56

  Fly   814 PIPAQ----ARLAPCHLH-GVYTQ---PFPAAPPPGLAAPPL--QQQHQPLIQAQQMISQATLTA 868
            |:.:|    |.:||.|.| |...|   |.|......:..|..  |..||..:..||::
Human    57 PVQSQPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLL------- 114

  Fly   869 QQQQRDVVAIATANLGPIEAPGAHGHP-HAHPHAHPHAHQLPPGIHITPLSGAAAAAATHHLHST 932
            :.|.|.:|:                || .:......|.|:|.|....    |........:|...
Human   115 EAQHRRLVS----------------HPRRSQERVSVHPHRLHPSFDF----GQLQTPQPRYLAEG 159

  Fly   933 AAAAAAVAAGAQITTAQ-QILFSSDRRTFPPHRRIPRFWTANHGHRHVLPPQSLAAHQAPVQIQA 996
            .....:|.||  ::.|| |:      |..|.|            ::|.|....:  |..|....:
Human   160 TDWDLSVDAG--LSPAQFQV------RPIPQH------------YQHYLATPRM--HHFPRNSSS 202

  Fly   997 TSGIIN-----PGFLLNFLAMFPLSPYNQHDLSSGDTNETENYEALLSLAERLGEAKPRGLTRNE 1056
            |..:::     |...|:|||:..|:|      |...:...|:||.||.|.:|||.. .||..:|.
Human   203 TQMVVHEIRNYPYPQLHFLALQGLNP------SRHTSAVRESYEELLQLEDRLGNV-TRGAVQNT 260

  Fly  1057 IDQLP-SYKFNP--------EVHNGDQS----SCVVCMCDFELRQLLRVLPCSHEFHAKCVDKWL 1108
            |::.. .:|:..        :...|::|    .|.:|:...|..:.:|.|||.|.||..|||:||
Human   261 IERFTFPHKYKKRRPQDGKGKKDEGEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWL 325

  Fly  1109 RSNRTCPICR 1118
            ..::.|||||
Human   326 AMSKKCPICR 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	18/41 (44%)
RNF165	NP_689683.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..76		19/72 (26%)
		Ubiquitin binding. /evidence=ECO:0000269\|PubMed:26656854, ECO:0007744\|PDB:5D0K	266..268		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..288		2/20 (10%)
		RING-H2_RNF111_like	292..337	CDD:319388	19/43 (44%)
		Ubiquitin binding. /evidence=ECO:0000269\|PubMed:26656854, ECO:0007744\|PDB:5D0K	309..313		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910