DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mura and Rnf44

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_006253695.1	Gene:	Rnf44 / 361212	RGDID:	1307212	Length:	433	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	173/558 - (31%)
Similarity:	224/558 - (40%)	Gaps:	176/558 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 GNNNGASTSTGGPG-LMGELPSGSGLSGSSLSLNNGPGGLNSDSPSRKRRRISGRPPNGPQPQHR 657
            |:...::..:..|| |.|.|    |..|...|    |...|...||   :::..|||:....:||
  Rat    18 GHCRVSTRPSSSPGQLWGSL----GHEGPLAS----PPAQNERLPS---QQLLPRPPHLSVEEHR 71

  Fly   658 CPMAHMQQGSPPLRRPRLRDVATSTQQQQQQYGHQVHHPQQQQQQPPSNYHPMHHHQPQP-HY-- 719
            ...|      |..|.||:.                  ||..||.....:.|...|..|.| .|
  Rat    72 ASEA------PAGRSPRML------------------HPATQQSPFMVDLHDQVHQGPVPLSYTV 112

  Fly   720 --VPQQQVPPPHVQRSPWDLGSSGGSSGGATSSSSVGPILQQVQAPPQPPSHQQAVGYPQAPPQP 782
              |..|..|.|..|..|                   |...||:.|.....|.|.   ||.....|
  Rat   113 TTVTTQGFPLPASQHIP-------------------GCSAQQLPACSVMFSGQH---YPLCCLPP 155

  Fly   783 ASLMVDLNLNQVPVNLQLRPSEPFWASFCTYPIPAQARLAPCHL----HGVYTQPFPAAPP-PGL 842
            ..|:....:.|:||            .:.|||          ||    |.:...|.||.|| |..
  Rat   156 PQLIQACTMQQLPV------------PYHTYP----------HLISSDHYILHPPPPAPPPQPTH 198

  Fly   843 AAP-----PLQQQHQPLIQAQQMISQATLTAQQQQRDVVAIATANLGPIEAPGA--HGHPHAHPH 900
            .||     .||.|| |.:..|::.::..|...|........:|:..||..:|..  |..||...|
  Rat   199 MAPLGQFVSLQTQH-PRMPLQRLDNEMDLRGDQHPLGSFTYSTSATGPTLSPSVPLHYLPHDPLH 262

  Fly   901 AH-----PHAHQLPPGIHITPLSGAAAAAATHHLHSTAAAAAAVAAGAQITTAQQILFSSDRRTF 960
            ..     |::|.:|                                 .:::|.:..|    ::..
  Rat   263 QELSFGVPYSHMMP---------------------------------RRLSTQRYRL----QQPL 290

  Fly   961 PPHRRIPRFWTANHGHRHVLPPQSLAAHQAPVQIQATSGIINPGFLLNFLAMFPLSPYN-----Q 1020
            ||....|             ||.                 ..|.||..||:|.|:||..     .
  Rat   291 PPPPPPP-------------PPS-----------------YYPSFLPYFLSMLPMSPTTVGPTIS 325

  Fly  1021 HDLSSGDTNETENYEALLSLAERLGEAKPRGLTRNEIDQLPSYKFNPEVHNGDQSSCVVCMCDFE 1085
            .||...|. |.|||||||:||||||:|||||||:.:|:|||||:|||:.|..:|:.||||..|||
  Rat   326 LDLDVDDV-EMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFNPDSHQSEQTLCVVCFSDFE 389

  Fly  1086 LRQLLRVLPCSHEFHAKCVDKWLRSNRTCPICRGNASD 1123
            :|||||||||:||||||||||||::||||||||.:||:
  Rat   390 VRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	34/41 (83%)
Rnf44	XP_006253695.1	zf-RING_2	381..422	CDD:290367	34/40 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGBB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003478
OrthoInspector	1	1.000	-	-		otm45716
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46171
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.870