DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mura and RNF115

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_055270.1	Gene:	RNF115 / 27246	HGNCID:	18154	Length:	304	Species:	Homo sapiens

Alignment Length:	201	Identity:	57/201 - (28%)
Similarity:	82/201 - (40%)	Gaps:	39/201 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   963 HRRIPRFWTANHGHRHVLPPQ-------SLAAHQAPVQIQATSGIIN---PGFLLNFLAMFPLSP 1017
            |:....||.|.       ||:       .......|.:..|..||:.   .||..|  :..|.||
Human   107 HQTHTDFWGAR-------PPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFAN--SAIPGSP 162

  Fly  1018 Y----------NQHDLSSGDTNETENYEALLSLAERLGEAKPRGLTRNEIDQLPSYKFNPE-VHN 1071
            :          |..|.:.|.|........||...|..|   |....:.:|..||:.....| |..
Human   163 HPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTG---PPPADKEKITSLPTVTVTQEQVDM 224

  Fly  1072 GDQSSCVVCMCDFELRQLLRVLPCSHEFHAKCVDKWLRSNRTCPICRGNASDYFDGVDQQQQSQA 1136
            |  ..|.||..|:.:.:.:|.|||:|.||:.|:..||..:.|||:||.:    .:|.|..:|||:
Human   225 G--LECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKS----LNGEDSTRQSQS 283

  Fly  1137 TAGAAA 1142
            |..:|:
Human   284 TEASAS 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	17/41 (41%)
RNF115	NP_055270.1	zinc_ribbon_9	19..49	CDD:316857
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..138		7/37 (19%)
		RING-H2_RNF115	226..272	CDD:319714	19/49 (39%)
		RING-H2 finger (C3H2C3-type)	228..268	CDD:319714	17/39 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..304		7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910