DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mura and SPCC4G3.12c

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_587826.1	Gene:	SPCC4G3.12c / 2539364	PomBaseID:	SPCC4G3.12c	Length:	821	Species:	Schizosaccharomyces pombe

Alignment Length:	1045	Identity:	195/1045 - (18%)
Similarity:	324/1045 - (31%)	Gaps:	363/1045 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 HTQMHTPHYPHSSSPQQSNSYRQYPPHSYSPNSPH--SNGHTNSNASNNPISQRSNPQAHPNQNQ 242
            |..:.:.:|..:.|....||...:|..:...:|.|  :..|.:...|::..   |:..|..:.:.
pombe    50 HFAVPSENYADTPSRNTPNSSNGFPSETLVTSSAHCSTQPHKDEAYSHHGY---SSTMALDDSSL 111

  Fly   243 NSNFYEMCTGSGGSHTYGSMSVSLVRLNPARLCLTLGPVTPPAQRVVSFGHRSHSHSNSSSNTSS 307
            ...::|...|:.|:                          .|.:|.:  |.....|...|.|:|.
pombe   112 AQTYHEYEEGTSGN--------------------------SPLRRAI--GSYDFLHPRPSGNSSR 148

  Fly   308 SDQNQHNPPPRSQNHHPNPHHSQYQYQYQYQYRYQYHPPHQYHPLHSP-QQQTNRQSLPLTRTNS 371
            .|:|...  |.:.:.|..|..|.|...                  :.| |::.|..|||   :||
pombe   149 LDRNSSR--PFTSSFHSAPFLSSYGSS------------------NDPSQERVNEYSLP---SNS 190

  Fly   372 NSINATTFNSTNPTTNSNPTDVVNVNSCTDIIPYGSSSTSSSASSMLPQQQQHQINNASAPINSH 436
            ||...|...|.|   |.:|...|..|:..                         :||:
pombe   191 NSTYTTPLQSIN---NEHPLPTVLENNAL-------------------------LNNS------- 220

  Fly   437 SQGQGPGNSPNLGHNHQRGY---------------NNGNNN-----RGIGNGIVNGNTNGPPDYM 481
                  ||||:| .||.|.|               .|.|:|     |...:.|.:...:.|.::.
pombe   221 ------GNSPSL-INHLRQYLNQDFSRLHQSPSPIPNSNDNDSQTRRSSWSSIASAFNDFPEEFP 278

  Fly   482 NYRRGVCPAQSRDYSGNGNGNNNG----------------HGHNGRRYMSDNLNNPSSSMNGLIN 530
            |.......:.....:||.....|.                .....|...|.|:.|...|....::
pombe   279 NASNPEAHSNFTPLNGNDESTVNMLSRLLSAAAIETVASIMNSEARNMDSQNMANGEPSRFRSVD 343

  Fly   531 SGHHQ--RNYNDRNLNNHFGNSEQNGGPDHRDRAEGSS--YNFMRNGGGSGGGGYGRNGSHYQHM 591
            ....|  .:....||.|...||.|||........|.:|  ..::|.        :.....|..|.
pombe   344 GSFEQFLTDLRSGNLTNVLQNSSQNGNDQISSDPESNSSDLQYLRM--------FRFPSFHQSHN 400

  Fly   592 AYGNNNGASTSTGGPGLMGEL---------------PSGSGLSGSSLSLNNGPGGLNSDSPSRKR 641
            ...:||.|| .|.||.|:..|               |:   ::..:.||:|           ..|
pombe   401 QPASNNEAS-DTNGPALVPVLIVCMRSISETSEDHAPT---MTQENQSLHN-----------ESR 450

  Fly   642 RRISGRPPNGPQPQHRCPMAHMQQGSPPLRRPRLRDVATSTQQQQQQYGHQVHHPQQQQQQPPSN 706
            ..||                             :.|:   |::..|........|...::...:.
pombe   451 ENIS-----------------------------INDI---TERMAQSTEFSTDLPPTFERSNSTF 483

  Fly   707 YHPMHHHQPQPHYVPQQQVP----PPHVQRSPWDLGSSGGSSGGATSSSS------------VGP 755
            .||    :|......|...|    |.::.....:|..:..|...:|||.|            ...
pombe   484 SHP----EPTRSDFSQAFTPVSDFPANLFPGSRNLFPTSNSGNQSTSSFSRYNQPTVSVDLRNSS 544

  Fly   756 ILQQVQAPPQPPSHQQAVGYPQAPPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTYPIPAQAR 820
            ||::.|.|....:.:..:|    ....:||:...|.|      ..||       |.|  :|:::.
pombe   545 ILRRAQEPVNGSTGENHIG----DDYISSLLDSSNSN------SQRP-------FST--VPSESN 590

  Fly   821 LAPCHLHGVYTQPFPAAPPPGLAAPPLQQQHQPLIQAQQMISQATLTAQQQQRDVVAIATANLGP 885
            :...:..|.::               :.|.|||                         .|.|...
pombe   591 VFSRNASGNFS---------------MSQTHQP-------------------------TTDNTSS 615

  Fly   886 IEA-PGAHGHPHAHPHAHPHAHQLPPGIHITPLSGAAAAAATHHLHSTAAAAAAVAAGAQITTAQ 949
            ... ||                :|..|:|..|        :...|.|.....:::|...:.  .:
pombe   616 FSTQPG----------------RLSTGLHHFP--------SDRDLLSNQTRRSSLARSYRF--EE 654

  Fly   950 QILFSSDRRTFPPHRRIPRFWTANHGHRHVLPPQSLAAHQAPVQIQAT------SGIINPGFLLN 1008
            |:....:...|                      .:||::.|...:..|      |...:..:|:.
pombe   655 QLSVDDNTSDF----------------------STLASNGAADMVTQTHSEGTFSNSTHGDWLIY 697

  Fly  1009 -FLAMFPLSPYNQHDLSSGDTNETEN--YEALLSLAERLGEAKPRGLTRNEIDQ---LPSYKFNP 1067
             |..:||    ..|.:.|..:..::|  ||.||:|...||.||....:..::.:   |.:|..:.
pombe   698 VFGGLFP----EHHPVLSTVSLFSDNPMYEDLLALTTYLGPAKKPVASHEDVKRSGGLFAYFDDA 758

  Fly  1068 EVHNGDQSSCVVCMCDFELRQLLRVL-PCSHEFHAKCVDKWLRS-NRTCPICRGNASDYFDGVDQ 1130
            .:.:.|  ||::|:..:....:.|.| .|.|.||..|:|:||.: |.:||:||.:      ||..
pombe   759 SLSSAD--SCLICLETYTNGDICRKLQACKHFFHQACIDQWLTTGNNSCPLCRAH------GVTT 815

  Fly  1131 QQQSQ 1135
            |.:.:
pombe   816 QAEEE 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	16/43 (37%)
SPCC4G3.12c	NP_587826.1	zf-RING_2	764..809	CDD:290367	17/46 (37%)
SPCC4G3.12c	NP_587826.1	zf-rbx1	<764..809	CDD:289448	17/46 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1687
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960