DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mura and Pja2

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_001020480.1	Gene:	Pja2 / 224938	MGIID:	2159342	Length:	707	Species:	Mus musculus

Alignment Length:	853	Identity:	155/853 - (18%)
Similarity:	246/853 - (28%)	Gaps:	298/853 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 DIIPYGSSSTSSSASSMLP--------QQQQHQINNASAPINSHSQGQGPGNSPNLGHNHQRGYN 457
            |.:|..::|.|||...:.|        ::.:.:|:.....:|     |...:||::.
Mouse    69 DDVPKENTSGSSSLDQVHPALPNEPTVEKSETEISTCGPALN-----QSTESSPSIA-------- 120

  Fly   458 NGNNNRGIGNGIVNGNTNGPPDYMNYRRGVCPAQSRDYSGNGNGNNNGHGHNGRRYMSDNLNNPS 522
                                        .||  .|.:.......|.|.|......: :..:.|.|
Mouse   121 ----------------------------TVC--HSEEVRETLESNTNLHNRTETEH-TPAVCNVS 154

  Fly   523 SSMNGLINSGHHQRNYNDRNLNNHFGNSEQNGGPDHRDRAEGSSYNFMRNG-----GGSGGGGYG 582
            |..||::..  |..:|:                ||.:....||    ::.|     ||....|.|
Mouse   155 SVQNGIMLV--HTDSYD----------------PDSKHDENGS----LQLGAEAVEGGRHQKGLG 197

  Fly   583 RNGSHYQHMAYGNNNG-----ASTSTGGPGLMGELPSG-----------SGLSGSSLSLNNGPGG 631
            |       ..:...||     |..|...|.|.||:...           |..:.:.|...||...
Mouse   198 R-------AVFELENGEAEIYADLSPSVPSLNGEISEAFEELDSAPLEKSSTADAELVHQNGQEF 255

  Fly   632 LNS--DSPSRKRRR---ISGRPPNGPQPQHRCPMAHMQQ---------GSPP--LRRPRLRDVAT 680
            ..|  |...||||:   ..||..........|...|::|         ||.|  :.||::|.|.:
Mouse   256 QRSSEDGVVRKRRQDDTDQGRQTENSTEDADCAPGHVEQNTSDRANHHGSSPEQVVRPKVRKVIS 320

  Fly   681 STQQQQQQYGHQVHHPQQQQQQ--------------PP----SNY---HPMHHHQPQPHYVPQQQ 724
            |: |..|:.|...|..:|:..|              .|    .:|   |......|....|.|::
Mouse   321 SS-QVDQEIGFNRHEAKQRSVQRWREALEVEECSSDDPIIKCDDYDGDHDCMFLTPTYSRVTQRE 384

  Fly   725 VPPPHVQRSPWDLGSSGGSSGGATSS-----------SSVGPILQQVQAPPQPPSHQQAVGYPQA 778
            .....|.           |..|||:|           ::.|...|....................
Mouse   385 TERNRVT-----------SENGATASGRQESRDNAFWNACGEYYQLFDKDEDSSECSDGEWSASL 438

  Fly   779 PPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTYPIPAQARLAPCHLHGVYTQPFPAAPPPGL- 842
            |.:.:....|.:           .|:..|.                      |.|......|.|
Mouse   439 PHRFSGTEKDQS-----------SSDDSWE----------------------TLPGKDENDPELQ 470

  Fly   843 ---AAPPLQQQHQPLIQAQQMISQATLTAQQQQRDVVAIATANLGPIEAPGAHGHPHAHPHAHPH 904
               :.|..:.|...|.:.:|...:.......|..:|          .|:....|:..|:..|.|.
Mouse   471 SDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEV----------NESSSDEGNEPANEFAQPE 525

  Fly   905 AHQLPPGIHITPLSGAAAAAATHHLHSTAAAAAAVAAGAQITTAQQILFSSDRRTFPPHRRIPRF 969
            |..|.               ..::|...::.:..:...
Mouse   526 AFMLD---------------GNNNLEDDSSVSEDLDVD--------------------------- 548

  Fly   970 WTANHGHRHVLPPQSLAAHQAPVQIQATSGIINPGFLLNFLAMFPLSPYNQHDLSSGDTNETENY 1034
            |:...|....|            .:......::|.| |.::|:       :..|:........:.
Mouse   549 WSLFDGFADGL------------GVAEAISYVDPQF-LTYMAL-------EERLAQAMETALAHL 593

  Fly  1035 EALLSLAERLGEAKPRGLTRNEIDQLPSYKFNPEVHN--GDQSSCVVCMCDFELRQLLRVLPCSH 1097
            |   |||..:..|.|.. ::..||.||. ....|.|.  |.:..|.:|..::....:...|||.|
Mouse   594 E---SLAVDVEVANPPA-SKESIDGLPE-TLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHH 653

  Fly  1098 EFHAKCVDKWLRSNRTCPICRGNASDYFDGVDQQQQSQATAGAAAALSGTSGGSAGVAGTSEASA 1162
            .||..||..||:.:.|||:||            :....|...|:||.|...        ..:||.
Mouse   654 FFHKPCVSIWLQKSGTCPVCR------------RHFPPAVIDASAAASSDP--------DPDASP 698

  Fly  1163 ATANPQQS 1170
            |..|.:::
Mouse   699 ANDNAEEA 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	15/41 (37%)
Pja2	NP_001020480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..120		11/52 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..314		17/63 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..405		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..493		12/101 (12%)
		Interaction with PRKAR1A, PRKAR2A and PRKAR2B. /evidence=ECO:0000250	530..707		48/264 (18%)
		zf-RING_2	633..674	CDD:290367	15/40 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..707		7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910