Protein Alignment mura and RNF38

DIOPT Version :10

• Sequence 1: NP_731367.2
• Gene: mura / 41145
• FlyBaseID: FBgn0037705
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_047278750.1
• Gene: RNF38 / 152006
• HGNCID: 18052
• Length: 619
• Species: Homo sapiens
• Alignment Length: 681
• Identity: 204/681 - (29%)
• Similarity: 262/681 - (38%)
• Gaps: 234/681 - (34%)

  Fly   556 PDHRDRAEGSSYNFMRNGGGSGGGGYGR---NGS----------HYQHMAYGNNNGASTSTGGPG 607
            |...||.....:..:| .|..|||..||   .||          |:.|:.:.:::..|.......
Human    54 PAATDRLSPPGHGPLR-AGAQGGGACGRAPGAGSVGASFQCQSIHHDHICHDDSDKISPGANSAS 117

  Fly   608 LMGE-----------------LPSGSGLSGSSLSLNNGPGGLNSDSPSRKRRRIS---------- 645
            |.|.                 |||....:... ..:......:.||||.||:|:|
Human   118 LPGHPNKVICERVRLQSLFPLLPSDQNTTVQE-DAHFKAFFQSEDSPSPKRQRLSHSVFDYTSAS 181

  Fly   646 ---------------GRPPNGPQPQH-----RCPMAHMQQGSPPLRRPRLRDVATSTQ---QQQQ 687
                           .:||:....||     ||......:.|||:||.|.|....|..   .|.:
Human   182 PAPSPPMRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDE 246

  Fly   688 QYGHQVHHPQQQQQQPPSNYHP-------MH--HHQPQ--------------------------- 716
            .| |.:.:.|||..:.|..:||       :|  .|.||
Human   247 NY-HHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVA 310

  Fly   717 PHYVP---QQQVPPPHVQRSPWDLGSSGGSSGGATSSSSVGPILQQ---VQAPPQPPSHQQAVGY 775
            ||.:|   .|.:|....|:.|   |.|...||......||.|.:.|   ||..|.|        |
Human   311 PHGIPLCTGQHIPACSTQQVP---GCSVVFSGQHLPVCSVPPPMLQACSVQHLPVP--------Y 364

  Fly   776 PQAPPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTYPIPAQARLAPCHLHGVYTQPFPAAPPP 840
            ...||                   |..|:|    |..:|    ..|:|.|       | |..|||
Human   365 AAFPP-------------------LISSDP----FLIHP----PHLSPHH-------P-PHLPPP 394

  Fly   841 GLAAP-PLQQQHQPLIQAQQMISQATLTAQQQQRDVVAIATANLGPIEAPGAHGHPHAHPHAHPH 904
            |...| ..||...||   |::.::..|                ||.....|...:|   |.|||.
Human   395 GQFVPFQTQQSRSPL---QRIENEVEL----------------LGEHLPVGGFTYP---PSAHPP 437

  Fly   905 AHQLPPGIHITPLSGAAAAAATHH-LHSTAAAAAAVAAGAQITTAQQILFSSDRRTFPPHRRIPR 968
            .  |||.   .||.     ..||. ||                  |::.|......|.|.|...|
Human   438 T--LPPS---APLQ-----FLTHDPLH------------------QEVSFGVPYPPFMPRRLTGR 474

  Fly   969 FWTANHGHRHVLPPQSLAAHQAPVQIQATSGIINPGFLLNFLAMFPLSP------YNQHDLSSGD 1027
               :.:..:..:||..                .:|..|...|:|.|:.|      ..:.|:..|
Human   475 ---SRYRSQQPIPPPP----------------YHPSLLPYVLSMLPVPPAVGPTFSFELDVEDG- 519

  Fly  1028 TNETENYEALLSLAERLGEAKPRGLTRNEIDQLPSYKFNPEVHNGDQSSCVVCMCDFELRQLLRV 1092
              |.|||||||:||||||||||||||:.:|:|||||:|||..|..:|:.|||||||||.||||||
Human   520 --EVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRV 582

  Fly  1093 LPCSHEFHAKCVDKWLRSNRTCPICRGNASD 1123
            |||:||||||||||||::||||||||.:||:
Human   583 LPCNHEFHAKCVDKWLKANRTCPICRADASE 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	RING-H2_RNF38-like	1073..1118	CDD:438135	37/44 (84%)
RNF38	XP_047278750.1	RING-H2_RNF38	545..611	CDD:438341	49/65 (75%)