DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mura and rnf43

DIOPT Version :9

Sequence 1:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis

Alignment Length:	318	Identity:	76/318 - (23%)
Similarity:	112/318 - (35%)	Gaps:	93/318 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   912 IHITPLSGAAAAAATHHLHSTAAAAAAVAAGAQITTAQQILF----------SSDRRTFPPHRRI 966
            |.:|||....:....   ..........|..|:|:.|:..|.          |.|.:|.|....|
Frog    39 IRVTPLQAEESGGVG---QGNLTLEGLFARVAEISPAEGRLLQFHPLSLCNTSEDDQTKPGFISI 100

  Fly   967 PRFWTANHGHRHVLPPQSLA----------AHQ----------APVQIQATSGIINPGFLL---- 1007
            .:..|.:   |...|..|||          ||.          |..|:|..:||..|..|:
Frog   101 VKLETPD---RDTQPCLSLANKARLAGERGAHAVLFDITNDRGALQQLQQPAGINQPVVLIWGPD 162

  Fly  1008 ----------NFLAMFPLSPYNQ-----HDL-----SSGDTNETENYEALLSLAERLGEAKP--- 1049
                      |..|:..:....|     ||:     .:|    |..:..|.::|..|....|
Frog   163 AEKLMDVVNKNKEALVKIEVQEQPKWLHHDIWILLTVAG----TVMFFVLYAVARLLCRQPPPQD 223

  Fly  1050 --RGLTRNEIDQLPSYKFNPEVHNGDQSS---------------CVVCMCDFELRQLLRVLPCSH 1097
              :..|...|.:|.:.::...:....::|               |.:|:.:|...|.||:|||.|
Frog   224 SIQQQTLLAISRLGTRRYQQRMLKDQRASGGWVETASTSSSVPVCAICLEEFTDGQELRILPCCH 288

  Fly  1098 EFHAKCVDKWLRSNRTCPICRGNASDYFDGVDQQQQSQATAGAAAA---LSGTSGGSA 1152
            |:|..|||.|||.|.|||:|      .:|.:|.....:..|..|.:   |.|...|||
Frog   289 EYHLGCVDPWLRQNHTCPLC------MYDILDSGTPPRPLAHRAPSQTQLWGRYPGSA 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	23/56 (41%)
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	22/104 (21%)
		HRD1	<244..366	CDD:227568	33/103 (32%)
		RING-H2_RNF43_like	267..311	CDD:319580	23/49 (47%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	22/39 (56%)
		DUF4573	523..643	CDD:373595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920