DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and tns2a

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_001921043.3	Gene:	tns2a / 799109	ZFINID:	ZDB-GENE-090312-163	Length:	1616	Species:	Danio rerio

Alignment Length:	817	Identity:	229/817 - (28%)
Similarity:	334/817 - (40%)	Gaps:	232/817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PYHARENSLP-FSYGIAKTSTPLRKTPTPTRVDSFLDFDFGPTNTNVN-------------SNSS 115
            ||....:.|| |::.......|....|:.:...:.||..:..:::...             |.|.
Zfish   855 PYGPHGHELPAFNFDPLPAGHPAYPEPSRSHSHAHLDLKYSSSSSGYQTPHQTCPCSPYQPSPSE 919

  Fly   116 SNNGGTGDMIK-----PPTRLTSPLLVRKTLGNAVSPTSSTNTNTIANTYHYTSSSATPTPVRDN 175
            |....:|...:     ||...:.|       |.....:..|...|..::.|:||.|.|..|..|:
Zfish   920 SRGYASGYQSESTSPLPPPSASCP-------GPVHHASGPTENQTDPHSQHFTSDSNTDCPGADS 977

  Fly   176 F--------EQLLRERREKVYNEYRNLD------RESSGERARVAPAPPQRQYYPSDGYGIGLKN 226
            .        ..|.|......|:...::.      ..||..|.:.:|:...|.|...:|   ..::
Zfish   978 IGWRNHITHGSLRRMHPHAPYSTPSDISGPPTPVHTSSPLRTQESPSLSVRDYDSREG---NSES 1039

  Fly   227 DSNGTLYRKSPSSNGKSTKYNYDFEFNLNLDDVRPEPTPYTTRNIHFEDLRLDQDVPDGVVNRRT 291
            .|..:|.|..|::                   ::|..|...:|...   |....:.|:
Zfish  1040 SSAHSLNRPHPAT-------------------IQPNMTNAGSRQTL---LSSSPETPE------- 1075

  Fly   292 MERNYHTINSLETT---------HKRQQLEPLEQLGAVYGQNHMEETLTRTRRDLSASTSTSKST 347
                   ||.|.||         |......|..|:...:......|         |.||....:.
Zfish  1076 -------INPLPTTPTTAQHLAAHSLPTTPPTPQIATEHSPPLTPE---------SESTQPQANC 1124

  Fly   348 SPLPAIGVPAIA----------------PASPIYATSTKRVSNPNTNGQQQMTPSPTSRPETPA- 395
            ||..|..:|.:.                |:||:.|.|..  ::..:||   :.|||.|....||
Zfish  1125 SPTAATVLPTVEMVPQSTETIKPAHSPHPSSPVLAESIP--AHMQSNG---VPPSPESDAPKPAS 1184

  Fly   396 -FPVTPRTPFG--ASSSS-------------------------------SASLAPT--------T 418
             .|.:|:.|.|  .||||                               |::..||        |
Zfish  1185 SAPASPQPPAGDHESSSSPEPSVPGFATLGRKLMLGSETSLSAGHSMDASSNSTPTFPVSPACCT 1249

  Fly   419 QLPPESIYQTGPRRGVP-PAL--------------------------QP---------------- 440
            ..||...|...|...|| |.|                          ||
Zfish  1250 PSPPPGSYPGCPSSSVPQPPLPEKRRPSGLPGSPNGRSGTLRASMSHQPSGQHHVTFSPSVGELA 1314

  Fly   441 -----LEVSAD-------SVQFARSSSQFWYKPNLTREDAIALLASAQPGTFLVRDSTTYKDSYG 493
                 :||..:       ||:|.:.||:|||||.::||.|||.|...:||.||:|||.:::.:||
Zfish  1315 VPIGQVEVGVEGEIGNRVSVKFVQDSSRFWYKPGISREQAIAALKEREPGAFLIRDSNSFQGAYG 1379

  Fly   494 LVVRVSQPPPG----------SQELVRHFLIEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQLA 548
            |.::|:.|||.          .::||||||||....||.:|||.:||.|.||||||::|||:.::
Zfish  1380 LALKVASPPPNVNNHSSKGDPLEQLVRHFLIETGPRGVKIKGCQNEPYFGSLSALVYQHSITPIS 1444

  Fly   549 LPCLLRLPDRDIVPPVRATTPAQQ-----HLLAHGAATNVLWLYSCDTESLTGNEAIRKAIRQMY 608
            |||.||:|::|.:..|....|...     .||..|||.|||:|.|.:||||||.:||.||.....
Zfish  1445 LPCALRIPEKDPIGDVVEVQPVSNMSTAADLLKQGAACNVLYLNSVETESLTGPQAIAKATGATL 1509

  Fly   609 GQQPLPQPTEVHFKVSSQGITLTDNTRKKFFRKHYKADVISHCAIDPENRMWTSEGESDKKTIFA 673
            .:.|.|..|.||||||:|||||||:.|:.|||:||..:.:::.:|||::|.||:...:..| :|.
Zfish  1510 SRSPRPSATVVHFKVSAQGITLTDSQRRVFFRRHYPINSVTYSSIDPQDRRWTNSDSTTSK-VFG 1573

  Fly   674 FVARRSHSSTDNQCHVFCDLSVSQPAAAIVSFANRTL 710
            |||::..|..:|.||:|.:|...|||.|||:|.|:.:
Zfish  1574 FVAKKPGSVAENVCHLFAELDPEQPATAIVNFINKVM 1610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	58/114 (51%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	65/133 (49%)
tns2a	XP_001921043.3	C1	45..91	CDD:237996
		PTPc_motif	205..325	CDD:214649
		PTEN_C2	313..440	CDD:313607
		Atrophin-1	<903..1322	CDD:331285	87/478 (18%)
		SH2_Tensin_like	1340..1455	CDD:198181	58/114 (51%)
		PTB_tensin	1479..1611	CDD:269924	65/133 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5004
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24267
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45734
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.040